药物诱导的急性肝衰竭 : 用于肝性脑病研究的硫代乙酰胺模型的关键评估。
关键词: ALT, alanine aminotransferase AQP4, aquaporin 4 water channel AST, aspartate aminotransferase Acute liver failure Animal model B7, B7 molecules (CD80+CD86) BBB, blood-brain barrier CBF, cerebral blood flow CCL2, chemokine ligand 2 CNS, central nervous system CTLA4, Cytotoxic T-lymphocyte-associated Protein 4 CYP2E1, Cytochrome P450 family 2 subfamily E member 1 GFAP, glial fibrillary acidic protein HE, hepatic encephalopathy Hepatic encephalopathy IL-6, interleukin 6 IL-β, interleukin 1 β Iba1, ionized calcium-binding adaptor molecule 1 JNK, c-Jun N-terminal kinase NAC, N-acetylcysteine NF-κB, nuclear factor κB OA, L-ornithine-l-aspartate ROS, reactive oxygen species TAA, thioacetamide TASO, thioacetamide sulfoxide TASO2, thioacetamide sulfdioxide TLR-2, toll-like receptor 2 TLR-4, toll-like receptor 4 TNFα, tumor necrosis factor α Thioacetamide Toxicity pathway
来 源:
DOI:10.1016/j.toxrep.2021.04.011
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