Cryptococcus meningitis presented with multiple cerebral infarcts in an immunocompetent patient.

在具有免疫能力的患者中 ， 隐球菌性脑膜炎伴多发性脑梗死。

• 发表时间: 2021
• 来源期刊: IDCases
• DOI: 10.1016/j.idcr.2021.e01154
• PMID: 34026541
• 文章类型: Case Reports
• 作者列表: Erturk Sengel B,Tukenmez Tigen E,Can Sarinoglu R,Midi I,Cerikcioglu N,Odabasi Z

关键词: Cerebral infarct; Cryptococcus neoformans; Film array; Hydrocephalus

Abstract

Cryptococcus neoformans is generally observed with immunosuppressive conditions. Rarely, it may be seen in immunocompetent individuals and presented with non-specific conditions. We described an immunocompetent case of cryptococcal meningitis presented with multiple cerebral infarcts. Despite the late diagnosis and emergence of hydrocephalus during treatment, the patient was recovered without any sequelae. In immunocompetent patients, the conventional diagnostics tests may be negative because of the low fungal load. If it is available, the Biofire FilmArray meningitis panel has high sensitivity and specificity for diagnosis.

摘要

新生隐球菌通常在免疫抑制条件下观察到。很少,它可以在有免疫能力的个体中看到，并且存在非特异性条件。我们描述了一例伴有多发性脑梗塞的隐球菌性脑膜炎的免疫活性病例。尽管晚期诊断和治疗期间出现脑积水，病人康复，没有任何后遗症。在有免疫能力的患者中，传统的诊断测试可能是阴性的，因为低真菌负荷。如果有的话,BiofireFilmArray脑膜炎小组对诊断具有很高的敏感性和特异性。