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Abstract：
Chronic respiratory disease (CRD) is an airflow limitation that represents a wide array of serious diseases. The aim of this study is to examine the influence of vitamin C deficiency on metabolic health-related quality in individuals with and without chronic respiratory disease in the Gaza Strip.
A matched case-control study including 52 cases of CRD and 52 controls of healthy participants were matched by age, sex, body mass index (BMI) and waist circumferences (WC). The study was conducted at the Ministry of Health secondary health-care centers in Gaza strip, Palestine. The biochemical data included Protein Carbonyl (PC), high sensitivity C reactive protein (CRP), vitamin C, fasting blood glucose (FBG) and markers of the lipid profile.
By the qualitative estimation of vitamin C consumption, there was a significantly lower consumption of foods that are rich in vitamin C by CRD patients than the matched controls. By comparing the results between both groups, CRD patients had significantly lower plasma concentrations of vitamins C than the control group (18.43 ± 11.93 μgm/ml vs. 24.06 ± 11.19 μgm/ml, P = 0.025), but significantly higher in PC (3.86 ± 4.21 μgm/ml vs. 2.11 ± 0.97 μgm/ml, P = 0.005), CRP (5.98 ± 8.84 mg/l vs. 1.87 ± 1.96 mg/l, P = 0.001), and FBG (102.46 ± 15.09 mg/dl vs. 95.92 ± 10.88 mg/dl, P = 0.017). The results revealed that CRD patients had significantly lower blood oxygen saturation than the control group (96.36 ± 3.81 vs. 98.51 ± 0.75, P < 0.001), whereas no significant differences were observed regarding the lipid profiles markers.
CRD patients have lower levels of vitamin C in their plasma and their diet than do healthy matched people; they also have higher oxidative stress and inflammatory markers than healthy people, which are risk factors for predicting metabolic complications.
A matched case-control study including 52 cases of CRD and 52 controls of healthy participants were matched by age, sex, body mass index (BMI) and waist circumferences (WC). The study was conducted at the Ministry of Health secondary health-care centers in Gaza strip, Palestine. The biochemical data included Protein Carbonyl (PC), high sensitivity C reactive protein (CRP), vitamin C, fasting blood glucose (FBG) and markers of the lipid profile.
By the qualitative estimation of vitamin C consumption, there was a significantly lower consumption of foods that are rich in vitamin C by CRD patients than the matched controls. By comparing the results between both groups, CRD patients had significantly lower plasma concentrations of vitamins C than the control group (18.43 ± 11.93 μgm/ml vs. 24.06 ± 11.19 μgm/ml, P = 0.025), but significantly higher in PC (3.86 ± 4.21 μgm/ml vs. 2.11 ± 0.97 μgm/ml, P = 0.005), CRP (5.98 ± 8.84 mg/l vs. 1.87 ± 1.96 mg/l, P = 0.001), and FBG (102.46 ± 15.09 mg/dl vs. 95.92 ± 10.88 mg/dl, P = 0.017). The results revealed that CRD patients had significantly lower blood oxygen saturation than the control group (96.36 ± 3.81 vs. 98.51 ± 0.75, P < 0.001), whereas no significant differences were observed regarding the lipid profiles markers.
CRD patients have lower levels of vitamin C in their plasma and their diet than do healthy matched people; they also have higher oxidative stress and inflammatory markers than healthy people, which are risk factors for predicting metabolic complications.
摘要：
慢性呼吸系统疾病（CRD）是一种气流限制，代表了一系列严重的疾病。这项研究的目的是研究维生素C缺乏对加沙地带有和没有慢性呼吸道疾病的个体的代谢健康相关质量的影响。
一项匹配的病例对照研究，包括52例CRD和52例健康参与者的对照，按年龄进行匹配，性别,体重指数（BMI）和腰围（WC）。这项研究是在加沙地带卫生部二级保健中心进行的，巴勒斯坦。生化数据包括羰基蛋白质(PC)，高敏C反应蛋白(CRP),维生素C,空腹血糖（FBG）和血脂指标。
通过对维生素C消耗的定性估计，CRD患者对富含维生素C的食物的消费量明显低于匹配的对照组.通过比较两组之间的结果，CRD患者的血浆维生素C浓度明显低于对照组（18.43±11.93μgm/mlvs.24.06±11.19μgm/ml,P=0.025),但在PC中明显更高（3.86±4.21μgm/ml与2.11±0.97μgm/ml,P=0.005),CRP（5.98±8.84mg/lvs.1.87±1.96毫克/升，P=0.001),和FBG（102.46±15.09mg/dlvs.95.92±10.88mg/dl,P=0.017)。结果显示，CRD患者的血氧饱和度明显低于对照组（96.36±3.81vs.98.51±0.75,P<0.001),而关于脂质特征标记没有观察到显著差异。
CRD患者的血浆和饮食中的维生素C水平低于健康匹配人群；他们的氧化应激和炎症标志物也高于健康人，这是预测代谢并发症的危险因素。
一项匹配的病例对照研究，包括52例CRD和52例健康参与者的对照，按年龄进行匹配，性别,体重指数（BMI）和腰围（WC）。这项研究是在加沙地带卫生部二级保健中心进行的，巴勒斯坦。生化数据包括羰基蛋白质(PC)，高敏C反应蛋白(CRP),维生素C,空腹血糖（FBG）和血脂指标。
通过对维生素C消耗的定性估计，CRD患者对富含维生素C的食物的消费量明显低于匹配的对照组.通过比较两组之间的结果，CRD患者的血浆维生素C浓度明显低于对照组（18.43±11.93μgm/mlvs.24.06±11.19μgm/ml,P=0.025),但在PC中明显更高（3.86±4.21μgm/ml与2.11±0.97μgm/ml,P=0.005),CRP（5.98±8.84mg/lvs.1.87±1.96毫克/升，P=0.001),和FBG（102.46±15.09mg/dlvs.95.92±10.88mg/dl,P=0.017)。结果显示，CRD患者的血氧饱和度明显低于对照组（96.36±3.81vs.98.51±0.75,P<0.001),而关于脂质特征标记没有观察到显著差异。
CRD患者的血浆和饮食中的维生素C水平低于健康匹配人群；他们的氧化应激和炎症标志物也高于健康人，这是预测代谢并发症的危险因素。
