关键词: Campylobacter jejuni erysipelas hypogammaglobulinemia

来  源:   DOI:10.1097/IPC.0000000000000827   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
A 51 year old man with active follicular lymphoma presented with several days of erythematous skin nodules on all extremities two weeks after a self-limited diarrheal illness. All serum immunoglobulin levels were found to be low. Blood cultures grew Campylobacter jejuni. The patient was given one week of azithromycin with complete resolution of his skin nodules. The literature of skin manifestations seen in active Campylobacter jejuni infection are reviewed. The majority of cases occur in immunocompromised hosts, many with low or no serum immunoglobulin levels. Postulated mechanisms include a lack of secretory IgA in intestinal mucosa predisposing susceptible patients to translocated enteric pathogens however the precise pathogenesis underlying cutaneous manifestations are unknown.
摘要:
一名患有活动性滤泡性淋巴瘤的51岁男子在自限性腹泻疾病两周后在所有四肢上出现了几天的红斑皮肤结节。发现所有血清免疫球蛋白水平都很低。血液培养培养空肠弯曲杆菌。患者接受了一周的阿奇霉素治疗,皮肤结节完全消退。综述了空肠弯曲杆菌活动性感染中皮肤表现的文献。大多数病例发生在免疫受损的宿主中,许多血清免疫球蛋白水平低或没有。推测的机制包括肠粘膜中缺乏分泌性IgA,易感患者易感肠道病原体,但皮肤表现的确切发病机理尚不清楚。
公众号