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Abstract：
UNASSIGNED: The aim of this study was to retrospectively investigate the clinical significance of anti-rods and rings (anti-RR) antibodies in nonhepatitis virus infection patients from Southwest China.Anti-RR antibodies were determined by indirect immunofluorescence assay in a group of 19,935 individuals with antinuclear antibodies test from January 2017 to December 2019. The laboratory and clinical data were collected. Finally, 66 samples with anti-RR antibodies (0.33%) were detected.In Wilcoxon rank sum test, gamma glutamyl transferase (Z = -3.364, P = .001), alpha-l-fucosidase (AFU) (Z = -2.312, P = .021), uric acid (Z = -1.634, P = .047) and red blood cell distribution width (Z = -2.285, P = .022) were higher in metabolic disease group than nonmetabolic disease group. In independent-samples t test, endogenous creatinine clearance was higher in metabolic disease group than nonmetabolic disease group (t = 2.061, P = .045). During the follow-up period of 37 patients with anti-RR antibodies for 1 to 60 months, the titers of anti-RR were significantly increased in the metabolic disease group (Z = -2.346, P = .019). In binary logistic regression analysis, triglycerides (odds ratio 3.679, 95% confidence interval 1.467-24.779, P = .048) was associated with elevated titers of anti-RR antibodies.In summary, anti-RR in non-hepatitis patients may be a manifestation of metabolic disorders, and has a certain correlation with routine laboratory indicators, which is worthy of the attention from clinicians.
摘要：
UNASSIGNED：本研究的目的是回顾性研究中国西南地区非肝炎病毒感染患者抗杆和环（抗RR）抗体的临床意义。从2017年1月至2019年12月，通过间接免疫荧光测定法对一组19,935名个体进行抗核抗体检测，测定抗RR抗体。收集实验室和临床数据。最后,检测到66个具有抗RR抗体的样品(0.33%)。在威尔科克森秩和检验中，γ-谷氨酰转移酶(Z=-3.364,P=.001),α-l-岩藻糖苷酶（AFU）（Z=-2.312，P=.021），代谢性疾病组的尿酸（Z=-1.634，P=0.047）和红细胞分布宽度（Z=-2.285，P=0.022）高于非代谢性疾病组。在独立样本t检验中，代谢性疾病组内源性肌酐清除率高于非代谢性疾病组(t=2.061,P=0.045).对37例抗RR抗体患者进行1～60个月的随访,代谢性疾病组的抗RR滴度显著升高(Z=-2.346,P=0.019).在二元逻辑回归分析中，甘油三酯(比值比3.679,95%置信区间1.467-24.779,P=0.048)与抗RR抗体滴度升高相关.总之,在非肝炎患者抗RR可能是代谢紊乱的表现，与实验室常规指标有一定的相关性,值得临床医生关注。
