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Abstract：
Cutibacterium acnes (also known as Propionibacterium acnes) has long been implicated in the pathogenesis of acne, inspiring both therapeutic and personal care approaches aiming to control the disease by controlling the bacterium. The purported association has made people with acne feel dirty and led to the-at times excessive-use of cleansers, antiseptics and antibiotics for the condition. However, recent evidence seems to weaken the case for C. acnes\' involvement. New genetics and molecular biology findings strongly suggest that abnormal differentiation of sebaceous progenitor cells causes comedones, the primary lesions in acne. Comodegenesis is initiated by androgens and is unlikely to be triggered by C. acnes, which probably doesn\'t affect sebaceous differentiation. Is there still a place for it in this understanding of acne? It is necessary to critically address this question because it has consequences for treatment. Antibiotic use for acne noticeably contributes to microbial drug resistance, which we can ill afford. In this Viewpoint, we explore if and how C. acnes (still) fits into the developing view on acne. We also briefly discuss the implications for therapy in the light of antibiotic resistance and the need for more targeted therapies.
摘要：
痤疮杆菌（也称为痤疮丙酸杆菌）长期以来一直与痤疮的发病机理有关，激发治疗和个人护理方法，旨在通过控制细菌来控制疾病。所谓的协会使痤疮患者感到肮脏，并导致有时过度使用清洁剂，防腐剂和抗生素的条件。然而,最近的证据似乎削弱了痤疮杆菌参与的理由。新的遗传学和分子生物学发现强烈表明，皮脂腺祖细胞的异常分化会导致粉刺，痤疮的原发病变。结肠癌是由雄激素引发的，不太可能由痤疮梭菌引发，这可能不会影响皮脂腺的分化。在对痤疮的这种理解中，它仍然存在吗？有必要批判性地解决这个问题，因为它对治疗有影响。用于痤疮的抗生素明显有助于微生物耐药性，我们负担不起。在这个观点中,我们探索痤疮C.（仍然）是否以及如何适合痤疮的发展观点。我们还简要讨论了抗生素耐药性和更有针对性的治疗需求对治疗的影响。
