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Abstract：
BACKGROUND: Idiopathic epiretinal membrane (iERM) is a common retinal disease in the elderly population. The exact pathogenesis of iERM is unknown. The present study aimed to evaluate the relationship between aqueous flare and morphology of iERM using swept-source optical coherence tomography (OCT).
METHODS: A consecutive series of 36 eyes of 33 patients with iERM and 109 control eyes of 109 patients were retrospectively examined. Aqueous flare measurements and OCT images were obtained on the same day. The average total retinal, inner retinal, outer retinal, and choroidal thicknesses were calculated using the thickness map mode with an Early Treatment Diabetic Retinopathy Study nine-zone grid that was divided into three zones. The maximum depth of the retinal folds in iERMs was manually measured. The correlation among flare value, maximum depth of folds, and retinal and choroidal thicknesses was evaluated. The morphological changes between the control eyes and the eyes with iERM in different stages were examined.
RESULTS: The result demonstrated a significant positive correlation between the aqueous flare value and total and inner retinal thicknesses in the early stage of iERM. There was a significant positive correlation between the maximum depth of folds and total and inner retinal thicknesses in the early stage of iERM, and the maximum depth of folds significantly increased in the advanced stage. The total and inner retinal thicknesses and proportion of inner retinal thickness significantly increased as the stage of iERM progressed.
CONCLUSIONS: The aqueous flare value was associated with retinal thickness in the early stage of iERM, which supports the idea that inflammation or breakdown of blood-ocular barrier is involved in the process of iERM formation. The maximum retinal folds increased as the stage of iERM progressed and retinal thickness increased, which indicates that the tangential force increases as the iERM stage progresses.
METHODS: A consecutive series of 36 eyes of 33 patients with iERM and 109 control eyes of 109 patients were retrospectively examined. Aqueous flare measurements and OCT images were obtained on the same day. The average total retinal, inner retinal, outer retinal, and choroidal thicknesses were calculated using the thickness map mode with an Early Treatment Diabetic Retinopathy Study nine-zone grid that was divided into three zones. The maximum depth of the retinal folds in iERMs was manually measured. The correlation among flare value, maximum depth of folds, and retinal and choroidal thicknesses was evaluated. The morphological changes between the control eyes and the eyes with iERM in different stages were examined.
RESULTS: The result demonstrated a significant positive correlation between the aqueous flare value and total and inner retinal thicknesses in the early stage of iERM. There was a significant positive correlation between the maximum depth of folds and total and inner retinal thicknesses in the early stage of iERM, and the maximum depth of folds significantly increased in the advanced stage. The total and inner retinal thicknesses and proportion of inner retinal thickness significantly increased as the stage of iERM progressed.
CONCLUSIONS: The aqueous flare value was associated with retinal thickness in the early stage of iERM, which supports the idea that inflammation or breakdown of blood-ocular barrier is involved in the process of iERM formation. The maximum retinal folds increased as the stage of iERM progressed and retinal thickness increased, which indicates that the tangential force increases as the iERM stage progresses.
摘要：
背景：特发性视网膜前膜（iERM）是老年人群常见的视网膜疾病。iERM的确切发病机制尚不清楚。本研究旨在使用扫频源光学相干断层扫描（OCT）评估房水耀斑与iERM形态之间的关系。
方法：对33例iERM患者的36只眼和109例对照眼的109只眼进行了回顾性研究。在同一天获得水性耀斑测量和OCT图像。平均总视网膜，内部视网膜,外视网膜,和脉络膜厚度使用厚度图模式与早期治疗糖尿病视网膜病变研究九区网格，分为三个区计算。手动测量iERM中视网膜褶皱的最大深度。耀斑值之间的相关性，褶皱的最大深度,评估视网膜和脉络膜厚度。检查了对照眼和不同阶段的iERM眼之间的形态变化。
结果：结果表明，在iERM的早期，房水耀斑值与总视网膜厚度和内部视网膜厚度之间存在显着正相关。iERM早期最大褶皱深度与总视网膜厚度和内视网膜厚度呈显著正相关,在晚期，褶皱的最大深度显着增加。随着iERM阶段的进展，总视网膜厚度和内部视网膜厚度以及内部视网膜厚度的比例显着增加。
结论：在iERM早期，房水耀斑值与视网膜厚度有关，这支持了iERM形成过程中涉及炎症或血眼屏障破坏的观点。随着iERM阶段的进展和视网膜厚度的增加，最大视网膜褶皱增加，这表明切向力随着iERM阶段的进行而增加。
方法：对33例iERM患者的36只眼和109例对照眼的109只眼进行了回顾性研究。在同一天获得水性耀斑测量和OCT图像。平均总视网膜，内部视网膜,外视网膜,和脉络膜厚度使用厚度图模式与早期治疗糖尿病视网膜病变研究九区网格，分为三个区计算。手动测量iERM中视网膜褶皱的最大深度。耀斑值之间的相关性，褶皱的最大深度,评估视网膜和脉络膜厚度。检查了对照眼和不同阶段的iERM眼之间的形态变化。
结果：结果表明，在iERM的早期，房水耀斑值与总视网膜厚度和内部视网膜厚度之间存在显着正相关。iERM早期最大褶皱深度与总视网膜厚度和内视网膜厚度呈显著正相关,在晚期，褶皱的最大深度显着增加。随着iERM阶段的进展，总视网膜厚度和内部视网膜厚度以及内部视网膜厚度的比例显着增加。
结论：在iERM早期，房水耀斑值与视网膜厚度有关，这支持了iERM形成过程中涉及炎症或血眼屏障破坏的观点。随着iERM阶段的进展和视网膜厚度的增加，最大视网膜褶皱增加，这表明切向力随着iERM阶段的进行而增加。
