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Abstract：
WNT signaling promotes the initiation and progression of pancreatic ductal adenocarcinoma (PDAC) through wide-ranging effects on cellular proliferation, survival, differentiation, stemness, and tumor microenvironment. Of therapeutic interest is a genetically defined subset of PDAC known to have increased WNT/β-catenin transcriptional activity, growth dependency on WNT ligand signaling, and response to pharmacologic inhibitors of the WNT pathway. Here we review mechanisms underlying WNT ligand addiction in pancreatic tumorigenesis, as well as the potential utility of therapeutic approaches that functionally antagonize WNT ligand secretion or frizzled receptor binding.
摘要：
WNT信号通过对细胞增殖的广泛影响促进胰腺导管腺癌（PDAC）的发生和进展，生存,分化,stemness,和肿瘤微环境。具有治疗意义的是已知具有增加的WNT/β-连环蛋白转录活性的遗传定义的PDAC子集。生长对WNT配体信号的依赖性，以及对WNT途径的药物抑制剂的反应。在这里，我们回顾了WNT配体成瘾在胰腺肿瘤发生中的潜在机制。以及功能性拮抗WNT配体分泌或卷曲受体结合的治疗方法的潜在用途。
