阿吡莫德改变 TGF β 信号通路并防止心脏纤维化重塑。
关键词: Apilimod Heart failure PIKfyve TGFβ. fibrotic remodeling
Mesh : Animals Cells, Cultured Drug Evaluation, Preclinical Fibroblasts / drug effects Fibrosis HEK293 Cells HeLa Cells Heart Failure / drug therapy pathology Humans Hydrazones / pharmacology therapeutic use Male Mice Mice, Inbred C57BL Morpholines / pharmacology therapeutic use Myocardium / pathology Phosphatidylinositol 3-Kinases / physiology Pyrimidines / pharmacology therapeutic use Rats Receptor, Transforming Growth Factor-beta Type II / drug effects Signal Transduction / drug effects Single-Blind Method Transforming Growth Factor beta / physiology Ventricular Dysfunction, Left / prevention & control Ventricular Remodeling / drug effects
来 源:
DOI:10.7150/thno.55821
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