Searches were undertaken for papers relating to extended stability of antimicrobials. Citations were included when antimicrobial shelf-life was assessed using a stability-indicating method and considered a period of storage, either refrigerated or at room temperature, followed by in-use testing at a temperature at or above 32°C.
Of 267 initial citations, six met the inclusion criteria and underwent full text review for data extraction. Included antimicrobials were cefazolin, ceftazidime, piperacillin/tazobactam, flucloxacillin and ceftolozane/tazobactam. Of these, only flucloxacillin and piperacillin demonstrated YCD compliant stability over the 24-hour infusion period while cefazolin, ceftazidime and ceftolozane/tazobactam could be infused over 12-hour period.
Contrary to the position found in 2017 review, high-quality data are now available to support the use of a number of antimicrobial agents in extended infusion in elastomeric devices for OPAT services. There is a need to expand the dataset, as well as developing international consensus on the ideal parameters for stability assessment of such infusions in elastomeric devices.
进行与抗微生物剂的延长稳定性相关的论文的搜索。当使用稳定性指示方法评估抗微生物剂保质期并将其视为储存期时,冷藏或在室温下,然后在32°C或以上的温度下进行使用测试。
在267次初始引用中,6人符合纳入标准,并接受了全文审查以进行数据提取.包括抗生素头孢唑啉,头孢他啶,哌拉西林/他唑巴坦,氟氯西林和头孢洛赞/他唑巴坦。其中,只有氟氯西林和哌拉西林在24小时输注期间表现出YCD顺应性稳定性,而头孢唑林,头孢他啶和头孢洛赞/他唑巴坦可以在12小时内输注。
与2017年评论中的立场相反,现在有高质量的数据支持在OPAT服务的弹性装置的延长输注中使用多种抗微生物剂。需要扩展数据集,以及就弹性体设备中此类输液稳定性评估的理想参数达成国际共识。