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Abstract：
Parkinson\'s Disease (PD) is among one of the common comorbidities in older patients. People with PD may be more vulnerable to severe pneumonia, due to the impairment of pulmonary function. Currently, the association between PD and COVID-19 is not yet established. This study aims to analyze the relationship between PD and in-hospital outcomes of COVID-19.
We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until December 25th, 2020. All articles published on COVID-19 and Parkinson\'s Disease were retrieved. The quality of the study was assessed using the Newcastle Ottawa Scale (NOS) tool for observational studies and Joanna Briggs Institute (JBI) Critical Appraisal Tools for cross-sectional studies. Statistical analysis was done using Review Manager 5.4 software.
A total of 12 studies with 103,874 COVID-19 patients were included in this meta-analysis. This meta-analysis showed that Parkinson\'s Disease was associated with poor in-hospital outcomes [[OR 2.64 (95% CI 1.75-3.99), p < 0.00001, I2 = 81%] and its subgroup which comprised of severe COVID-19 [OR 2.61 (95% CI 1.98-3.43), p < 0.00001, I2 = 0%] and mortality from COVID-19 [RR 2.63 (95% CI 1.50-4.60), p = 0.0007, I2 = 91%]. Meta-regression showed that the association was influenced by age (p = 0.05), but not by gender (p = 0.46) and dementia (p = 0.23).
Extra care and close monitoring should be provided to Parkinson\'s Disease patients to minimize the risk of infections, preventing the development of severe and mortality outcomes.
We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until December 25th, 2020. All articles published on COVID-19 and Parkinson\'s Disease were retrieved. The quality of the study was assessed using the Newcastle Ottawa Scale (NOS) tool for observational studies and Joanna Briggs Institute (JBI) Critical Appraisal Tools for cross-sectional studies. Statistical analysis was done using Review Manager 5.4 software.
A total of 12 studies with 103,874 COVID-19 patients were included in this meta-analysis. This meta-analysis showed that Parkinson\'s Disease was associated with poor in-hospital outcomes [[OR 2.64 (95% CI 1.75-3.99), p < 0.00001, I2 = 81%] and its subgroup which comprised of severe COVID-19 [OR 2.61 (95% CI 1.98-3.43), p < 0.00001, I2 = 0%] and mortality from COVID-19 [RR 2.63 (95% CI 1.50-4.60), p = 0.0007, I2 = 91%]. Meta-regression showed that the association was influenced by age (p = 0.05), but not by gender (p = 0.46) and dementia (p = 0.23).
Extra care and close monitoring should be provided to Parkinson\'s Disease patients to minimize the risk of infections, preventing the development of severe and mortality outcomes.
摘要：
帕金森病(PD)是老年患者常见的合并症之一。PD患者可能更容易患严重肺炎,由于肺功能受损。目前,PD和COVID-19之间的关联尚未确定。本研究旨在分析PD与COVID-19住院结局之间的关系。
我们使用与我们的目标相关的特定关键字系统地搜索了PubMed和EuropePMC数据库，直到12月25日，2020年。检索了所有发表在COVID-19和帕金森病上的文章。使用用于观察性研究的纽卡斯尔渥太华量表（NOS）工具和用于横断面研究的乔安娜·布里格斯研究所（JBI）关键评估工具评估研究质量。使用ReviewManager5.4软件进行统计分析。
共有12项研究纳入了103,874例COVID-19患者。这项荟萃分析显示，帕金森病与不良的住院结局相关[[OR2.64（95％CI1.75-3.99），p<0.00001，I2=81%]及其包括重症COVID-19的亚组[OR2.61（95%CI1.98-3.43），p<0.00001，I2=0%]和COVID-19的死亡率[RR2.63（95%CI1.50-4.60），p=0.0007，I2=91%]。Meta回归显示，该关联受年龄影响(p=0.05)，但不按性别（p=0.46）和痴呆（p=0.23）。
应向帕金森病患者提供额外护理和密切监测，以最大限度地降低感染风险，防止严重和死亡结局的发展。
我们使用与我们的目标相关的特定关键字系统地搜索了PubMed和EuropePMC数据库，直到12月25日，2020年。检索了所有发表在COVID-19和帕金森病上的文章。使用用于观察性研究的纽卡斯尔渥太华量表（NOS）工具和用于横断面研究的乔安娜·布里格斯研究所（JBI）关键评估工具评估研究质量。使用ReviewManager5.4软件进行统计分析。
共有12项研究纳入了103,874例COVID-19患者。这项荟萃分析显示，帕金森病与不良的住院结局相关[[OR2.64（95％CI1.75-3.99），p<0.00001，I2=81%]及其包括重症COVID-19的亚组[OR2.61（95%CI1.98-3.43），p<0.00001，I2=0%]和COVID-19的死亡率[RR2.63（95%CI1.50-4.60），p=0.0007，I2=91%]。Meta回归显示，该关联受年龄影响(p=0.05)，但不按性别（p=0.46）和痴呆（p=0.23）。
应向帕金森病患者提供额外护理和密切监测，以最大限度地降低感染风险，防止严重和死亡结局的发展。
