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Abstract：
Firefighters have an elevated risk of cancer, which is suspected to be caused by occupational and environmental exposure to fire smoke. Among many substances from fire smoke contaminants, one potential source of toxic exposure is polycyclic aromatic hydrocarbons (PAH). The goal of this paper is to identify the association between PAH exposure levels and contributing risk factors to derive best estimates of the effects of exposure on structural firefighters\' working environment in fire. We surveyed four databases (Embase, Medline, Scopus, and Web of Science) for this systematic literature review. Generic inverse variance method for random effects meta-analysis was applied for two exposure routes-dermal and inhalation. In dermal, the neck showed the highest dermal exposure increased after the fire activity. In inhalation, the meta-regression confirmed statistically significant increases in PAH concentrations for longer durations. We also summarized the scientific knowledge on occupational exposures to PAH in fire suppression activities. More research into uncontrolled emergency fires is needed with regard to newer chemical classes of fire smoke retardant and occupational exposure pathways. Evidence-based PAH exposure assessments are critical for determining exposure-dose relationships in large epidemiological studies of occupational risk factors.
摘要：
消防员患癌症的风险更高，怀疑是由职业和环境暴露于火灾烟雾引起的。在许多来自火灾烟雾污染物的物质中，毒性暴露的一个潜在来源是多环芳烃(PAH)。本文的目的是确定PAH暴露水平与危险因素之间的关系，以得出暴露对火灾中结构性消防员工作环境的影响的最佳估计。我们调查了四个数据库(Embase，Medline,Scopus,和WebofScience)进行这篇系统的文献综述。随机效应荟萃分析的通用逆方差方法应用于皮肤和吸入两种暴露途径。在真皮中，火灾后颈部皮肤暴露量最高。在吸入中，荟萃回归证实,在较长时间内,PAH浓度有统计学意义的增加.我们还总结了有关灭火活动中PAH职业暴露的科学知识。对于新的化学类别的阻燃剂和职业暴露途径，需要对不受控制的紧急火灾进行更多的研究。基于证据的PAH暴露评估对于确定职业危险因素的大型流行病学研究中的暴露剂量关系至关重要。
