PDF(Pubmed)
Abstract：
The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation have proven difficult, at least partly due to the broad involvement of Notch signaling in regenerative and homeostatic processes. In this review, we summarize the supporting role of Notch signaling in various inflammation-driven diseases, and highlight efforts to intervene with this pathway by targeting Notch ligands and/or receptors with distinct therapeutic strategies, including antibody designs. We discuss this in light of lessons learned from Notch targeting in cancer treatment. Finally, we elaborate on the impact of individual Notch members in inflammation, which may lay the foundation for development of therapeutic strategies in chronic inflammatory diseases.
摘要：
Notch信号通路调节发育细胞命运决定，最近也与炎性疾病有关。尽管理论上针对炎症中的Notch信号传导的疗法很有吸引力，他们的设计和实施被证明是困难的，至少部分是由于Notch信号广泛参与再生和稳态过程。在这次审查中,我们总结了Notch信号在各种炎症驱动的疾病中的支持作用，并强调通过以不同的治疗策略靶向Notch配体和/或受体来干预该途径的努力，包括抗体设计。我们从Notch靶向治疗癌症的经验教训中讨论了这一点。最后,我们详细阐述了个别Notch成员在炎症中的影响，这可能为制定慢性炎症性疾病的治疗策略奠定基础。
