PDF(Pubmed)
Abstract：
Epidermolytic acanthoma (EA) is a rare benign tumor, which usually appears as a solitary small papule. However, there are a few case reports of multiple EA, most of which occurs on the genital area. Cases of multiple EA may mimic verruca vulgaris, condyloma accuminatum, seborrheic keratosis, and bowenoid papulosis, and therefore, can be easily misdiagnosed. A 78-year-old male presented with a 2-week history of discrete, small skin-colored papules around the anus. The other case involved a 47-year-old male with a 5-year history of skin-colored papules on the scrotum. Skin biopsy of both cases revealed a well-demarcated papular lesion characterized by compact hyperkeratosis, perinuclear vacuolization, and reticular degeneration in the granular and upper spinous layer with coarse basophilic keratohyalin granules. Epidermal invagination was consistent with a cup-shaped type of EA. Both cases tested negative for human papillomavirus. We report typical cases of multiple EA, which should be considered as the differential diagnosis of small skin-colored papules in the anogenital area, to prevent the misdiagnosis.
摘要：
表皮松解性棘皮瘤（EA）是一种罕见的良性肿瘤，通常表现为孤立的小丘疹。然而,有一些多重EA的病例报告，其中大部分发生在生殖器区域。多发性EA的病例可能模仿寻常疣，尖锐湿疣,脂溢性角化病,和鲍温样丘疹病，因此,很容易被误诊。一名78岁的男性，有2周的离散病史，肛门周围有皮肤颜色的小丘疹.另一例涉及一名47岁的男性，阴囊上有5年的皮肤丘疹病史。两种情况的皮肤活检都显示出明显的丘疹性病变，其特征是紧凑型角化过度。核周空泡化,颗粒状和上棘层网状变性，碱性角化透明颗粒较粗。表皮内陷与杯形类型的EA一致。两例人乳头瘤病毒检测均为阴性。我们报告了多个EA的典型案例，这应该被认为是在肛门生殖器区域的小皮肤颜色的丘疹的鉴别诊断，以防止误诊。
