PDF(Pubmed)
Abstract：
Small-cell lung cancer (SCLC) is a very fast growing form of cancer and is characterised by early metastasis. As a result, chemotherapy is the mainstay of treatment. Platinum-containing combination regimens are the current treatment of choice for limited stage-SCLC and extensive stage SCLC. Various adverse effects after cisplatin and etoposide chemotherapy include nausea, nephrotoxicity, cardiotoxicity, hepatotoxicity, neurotoxicity, alopecia, gastrointestinal toxicity and myelosuppression. However, severe headache has not been reported yet. Here, we report one such case of severe refractory headache postcisplatin and etoposide chemotherapy which responded only to change in chemotherapy regime. All pertinent causes of headache were ruled out prior to changing the chemotherapy regimen.
摘要：
小细胞肺癌（SCLC）是一种非常快速生长的癌症形式，其特征是早期转移。因此,化疗是治疗的主要手段。含铂的组合方案是目前治疗有限期SCLC和广泛期SCLC的选择。顺铂和依托泊苷化疗后的各种不良反应包括恶心，肾毒性，心脏毒性,肝毒性，神经毒性，脱发,胃肠道毒性和骨髓抑制。然而,严重的头痛还没有报告。这里,我们报告了一例严重难治性头痛的顺铂和依托泊苷化疗后，仅对化疗方案的改变有反应。在改变化疗方案之前，排除了所有相关的头痛原因。
