关键词: Pfizer-BioNTech COVID-19 vaccine flu-like symptoms hypersensitivity injection site pain online survey side effects

来  源:   DOI:10.2147/IJGM.S310497   PDF(Pubmed)

Abstract:
UNASSIGNED: The Pfizer-BioNTech COVID-19 vaccine has recently received emergency approval from the US FDA. The mRNA technology was used to manufacture the Pfizer vaccine; however, as a pioneering technology that has never been used in the manufacture of vaccines, many people have concerns about the vaccine\'s side effects. Thus, the current study aimed to track the short-term side effects of the vaccine.
UNASSIGNED: The information in this study was gathered by a Google Form-questionnaire (online survey). The results included the responses of 455 individuals, all of whom are Saudi Arabia inhabitants. Adverse effects of the vaccine were reported after the first and the second doses.
UNASSIGNED: The most common symptoms were injection site pain, headaches, flu-like symptoms, fever, and tiredness. Less common side effects were a fast heartbeat, whole body aches, difficulty breathing, joint pain, chills, and drowsiness. Rare side effects include Bell\'s palsy and lymph nodes swelling and tenderness. Flu-like symptoms were more common among those under 60 years of age, while injection site pain was more frequent among recipients who were 60 years and older. The study revealed a significant increase in the number of females who suffered from the vaccine side effects compared to males. Difficulty of breathing was more reported among recipients who had been previously infected with the coronavirus compared to those who had not been previously infected.
UNASSIGNED: Most of the side effects reported in this study were consistent with Pfizer\'s fact sheet for recipients and caregivers. Further studies are required to determine the long-term side effects.
摘要:
辉瑞-BioNTechCOVID-19疫苗最近获得了美国FDA的紧急批准。mRNA技术用于制造辉瑞疫苗;然而,作为一种从未用于疫苗生产的开创性技术,许多人担心疫苗的副作用。因此,本研究旨在追踪疫苗的短期副作用。
本研究中的信息是通过Google表格问卷(在线调查)收集的。结果包括455个人的反应,他们都是沙特阿拉伯居民。在第一剂和第二剂之后报告了疫苗的不良反应。
最常见的症状是注射部位疼痛,头痛,流感样症状,发烧,和疲倦。不太常见的副作用是心跳加快,全身疼痛,呼吸困难,关节痛,发冷,和困倦。罕见的副作用包括贝尔氏麻痹和淋巴结肿大和压痛。流感样症状在60岁以下的人群中更为常见,而注射部位疼痛在60岁及以上的受者中更为常见。研究表明,与男性相比,遭受疫苗副作用的女性人数显着增加。与以前未感染的患者相比,以前感染过冠状病毒的患者呼吸困难的报道更多。
本研究报告的大多数副作用与辉瑞公司针对接受者和护理人员的情况说明书一致。需要进一步的研究来确定长期的副作用。
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