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Abstract：
UNASSIGNED: The aim of this study was to investigate the expression of phosphatase of regenerating live-3 (PRL-3) in human stage III colorectal cancer (CRC) and to evaluate its correlation with metachronous liver metastasis (MLM) and prognosis.The retrospective cohort study included 116 stage III CRC primary tumors and 60 normal colorectal tissues. PRL-3 expression was measured by immunohistochemistry. We investigated the correlation of PRL-3 with clinicopathologic features by the chi-square test. The association of PRL-3 expression with MLM was assessed by binary logistic regression. Overall survival (OS) and disease-free survival (DFS) between patients with positive PRL-3 expression and those with negative PRL-3 expression were compared by the Kaplan-Meier method and Cox proportional hazards regression model.We found that 32.8% of stage III CRC primary tumors were PRL-3 positive, and 15.0% of normal colorectal epithelia showed high PRL-3 expression (P = .012). Seventeen tumors (47.2%) among 36 cases that developed MLM were PRL-3 positive, and only 21 tumors (26.3%) in the 80 cases that did not develop MLM had positive PRL-3 expression (P = .026). PRL-3 expression was associated with MLM (P = .028). Patients with positive expression of PRL-3 showed a significantly shorter OS (40.32 ± 3.97 vs 53.96 ± 2.77 months, P = .009) and DFS (34.97 ± 4.30 vs 44.48 ± 2.89 months, P = .036). A multivariate analysis indicated that PRL-3 expression was an independent unfavorable prognostic factor for OS (P = .007).Our study suggested that high PRL-3 expression is an independent risk factor for MLM and poor prognosis. PRL-3 is expected to be a promising biomarker for predicting the incidence of MLM and prognosis in patients with stage III CRC.
摘要：
■本研究的目的是研究人III期结直肠癌（CRC）中再生live-3（PRL-3）磷酸酶的表达，并评估其与异时肝转移（MLM）和预后的相关性。回顾性队列研究包括116个III期CRC原发性肿瘤和60个正常结直肠组织。通过免疫组织化学测量PRL-3表达。我们通过卡方检验研究了PRL-3与临床病理特征的相关性。通过二元逻辑回归评估PRL-3表达与MLM的相关性。采用Kaplan-Meier法和Cox比例风险回归模型比较PRL-3表达阳性和PRL-3表达阴性患者的总生存期(OS)和无病生存期(DFS)。我们发现32.8％的III期CRC原发肿瘤为PRL-3阳性，15.0%的正常结直肠上皮显示PRL-3高表达(P=0.012)。36例MLM患者中17例(47.2%)为PRL-3阳性,80例未发生MLM的病例中只有21例(26.3%)PRL-3表达阳性(P=0.026)。PRL-3表达与MLM相关(P=.028)。PRL-3阳性表达患者的OS明显缩短(40.32±3.97vs53.96±2.77个月,P=.009）和DFS（34.97±4.30vs44.48±2.89个月，P=.036）。多变量分析表明，PRL-3表达是OS的独立不良预后因素（P=0.007）。我们的研究表明，高PRL-3表达是MLM和不良预后的独立危险因素。PRL-3有望成为预测III期CRC患者MLM发生率和预后的有希望的生物标志物。
