PDF(Sci-hub)
Abstract：
BACKGROUND: Various graft materials that are classified as autografts, xenografts, and allografts based on their origin have been used to endoscopically repair skull base defects. Tutoplast® (Tutogen Medical GmbH), an allogeneic natural collagen matrix, is processed through chemical sterilization that preserves tissue biocompatibility and structural integrity.
OBJECTIVE: To study the safety and efficacy of Tutoplast Fascia Lata and Tutoplast Temporalis Fascia® as primary graft materials in the endoscopic reconstruction of skull base defects of different sizes and etiologies and to compare the outcomes with those of other traditional graft materials based on our experience.
METHODS: This is a multi-center retrospective chart review of patients who underwent cerebrospinal fluid leak (CSF) endoscopic reconstruction with Tutoplast Fascia Lata or Tutoplast Temporalis Fascia as either a stand-alone reconstruction material or a part of a multilayer reconstruction depending on the defect at Prince Sultan Military Medical City and King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia, between 2017 and 2020. Our inclusion criteria were CSF leak repair with Tutoplast and a transnasal endoscopic approach. We reviewed demographic data, intraoperative and postoperative complications, repair materials, repair failure, defect size and location.
RESULTS: Tutoplast® was used as the primary graft material in 33 cases. Our main outcome was repair success with lack of post operative CSF leak, observed in 30 cases (90.9%). There was no significant association between postoperative CSF leaks and factors including different defect sizes, defect sites, demographic data, hospitalization duration, or postoperative radiation in oncological cases.
CONCLUSIONS: Tutoplast alone or in combination with other materials can be used safely and effectively for skull base defects repair.
OBJECTIVE: To study the safety and efficacy of Tutoplast Fascia Lata and Tutoplast Temporalis Fascia® as primary graft materials in the endoscopic reconstruction of skull base defects of different sizes and etiologies and to compare the outcomes with those of other traditional graft materials based on our experience.
METHODS: This is a multi-center retrospective chart review of patients who underwent cerebrospinal fluid leak (CSF) endoscopic reconstruction with Tutoplast Fascia Lata or Tutoplast Temporalis Fascia as either a stand-alone reconstruction material or a part of a multilayer reconstruction depending on the defect at Prince Sultan Military Medical City and King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia, between 2017 and 2020. Our inclusion criteria were CSF leak repair with Tutoplast and a transnasal endoscopic approach. We reviewed demographic data, intraoperative and postoperative complications, repair materials, repair failure, defect size and location.
RESULTS: Tutoplast® was used as the primary graft material in 33 cases. Our main outcome was repair success with lack of post operative CSF leak, observed in 30 cases (90.9%). There was no significant association between postoperative CSF leaks and factors including different defect sizes, defect sites, demographic data, hospitalization duration, or postoperative radiation in oncological cases.
CONCLUSIONS: Tutoplast alone or in combination with other materials can be used safely and effectively for skull base defects repair.
摘要：
背景：分类为自体移植物的各种移植材料，异种移植物,基于来源的同种异体移植物已用于内窥镜修复颅底缺损。Tutoplast®(TutogenMedicalGmbH),同种异体天然胶原基质,通过化学灭菌处理，保持组织生物相容性和结构完整性。
目的：研究TutoplastFasciaLata和TutoplastTemporalisFascia®作为主要移植材料在内窥镜重建不同大小和病因的颅底缺损中的安全性和有效性，并根据我们的经验与其他传统移植材料进行比较。
方法：这是对接受脑脊液漏（CSF）内窥镜重建的患者的多中心回顾性图表审查，其中TutoplastFasciaLata或TutoplastTemporalisFascia作为独立重建材料或多层重建的一部分，具体取决于苏丹王子军事医学城和利雅得费萨尔国王专科医院和研究中心的缺陷，沙特阿拉伯,从2017年到2020年。我们的纳入标准是使用Tutoplast和经鼻内窥镜方法修复CSF泄漏。我们审查了人口统计数据，术中和术后并发症，修复材料,维修失败,缺陷的大小和位置。
结果：33例采用Tutoplast®作为主要移植材料。我们的主要结果是修复成功，没有术后脑脊液漏，30例（90.9%）。术后脑脊液渗漏与不同缺损大小等因素之间无显著关联，缺陷位点,人口统计数据，住院时间，或肿瘤病例的术后放疗。
结论：Tutotoplast单独或与其他材料联合使用可安全有效地修复颅底缺损。
目的：研究TutoplastFasciaLata和TutoplastTemporalisFascia®作为主要移植材料在内窥镜重建不同大小和病因的颅底缺损中的安全性和有效性，并根据我们的经验与其他传统移植材料进行比较。
方法：这是对接受脑脊液漏（CSF）内窥镜重建的患者的多中心回顾性图表审查，其中TutoplastFasciaLata或TutoplastTemporalisFascia作为独立重建材料或多层重建的一部分，具体取决于苏丹王子军事医学城和利雅得费萨尔国王专科医院和研究中心的缺陷，沙特阿拉伯,从2017年到2020年。我们的纳入标准是使用Tutoplast和经鼻内窥镜方法修复CSF泄漏。我们审查了人口统计数据，术中和术后并发症，修复材料,维修失败,缺陷的大小和位置。
结果：33例采用Tutoplast®作为主要移植材料。我们的主要结果是修复成功，没有术后脑脊液漏，30例（90.9%）。术后脑脊液渗漏与不同缺损大小等因素之间无显著关联，缺陷位点,人口统计数据，住院时间，或肿瘤病例的术后放疗。
结论：Tutotoplast单独或与其他材料联合使用可安全有效地修复颅底缺损。
