We will search candidate studies that assessing the accuracy of NAATs for diagnosis of NTM through PubMed, Embase and the Cochrane Library until May 2021. Studies with full text that meet the inclusion criteria will be included. Following a revised tool for Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2), two researchers will independently evaluate the study quality. The STATA software (version 15.0) will be used to carry out meta-analyses. When heterogeneity is observed, subgroup analyses and meta-regression analyses will be used to explore sources of heterogeneity. Sensitivity analyses will be used to check the robustness of analyses.
We hope that this study will provide meaningful evidence for the early and rapid diagnosis of NAATs for NTM, which will help to guide the treatment of NTM and improve the prognosis of patients.
我们将通过PubMed搜索评估NAAT诊断NTM准确性的候选研究,Embase和Cochrane图书馆,直到2021年5月。将包括符合纳入标准的全文研究。在修订后的诊断准确性研究质量评估工具(QUADAS-2)之后,两名研究人员将独立评估研究质量。STATA软件(15.0版)将用于进行荟萃分析。当观察到异质性时,亚组分析和荟萃回归分析将用于探索异质性的来源.灵敏度分析将用于检查分析的稳健性。
我们希望这项研究将为NTM的NAAT的早期和快速诊断提供有意义的证据。有助于指导NTM的治疗,改善患者的预后。