PDF(Pubmed)
Abstract：
Despite decades of study, debate persists over the role of inflammation, fibrosis, and prostaglandins in the histopathology of androgenic alopecia (AGA). This brief review proposes that inconsistent findings across histological studies are a consequence of three inadequately controlled variables: 1) biopsy location, 2) hair diameter diversity (HDD), and 3) relative hair follicle miniaturization (HFM) within and across subjects. We suggest new methodological considerations to improve AGA histopathological research, as well as a novel classification system to quantify HFM by its stages. Finally, we hypothesize a dynamic relationship between inflammation, fibrosis, and prostaglandin activity dependent on relative HFM.
摘要：
尽管经过了几十年的研究,关于炎症的作用的争论仍然存在，纤维化，和前列腺素在雄激素性脱发（AGA）的组织病理学中。这篇简短的综述提出，组织学研究的不一致发现是三个控制变量不足的结果：1）活检位置，2）头发直径多样性（HDD），和3)受试者内部和跨受试者的相对毛囊小型化(HFM)。我们建议新的方法学考虑，以改善AGA组织病理学研究，以及一种新颖的分类系统，用于按阶段量化HFM。最后,我们假设炎症之间存在动态关系，纤维化，和前列腺素活性依赖于相对HFM。
