UNASSIGNED: We describe the hospital course, laboratory data, and treatment of 2 patients and provide a literature review.
UNASSIGNED: Both of our patients were found to have normal or mildly elevated serum glucose levels, with an elevated anion gap and ketosis, representative of euDKA. The first patient developed euDKA after only 1 dose of empagliflozin, while the second patient developed euDKA after only 1 week of being on a ketogenic diet while on an SGLT2 inhibitor.
UNASSIGNED: While there have been a few reports of euDKA with SGLT2 inhibitors and ketogenic diets, many physicians prescribing these medications may not be aware of this association. Therefore, they must inform their patients to avoid a ketogenic diet if on an SGLT2 inhibitor. If a patient presents with symptoms of DKA and is eating a carbohydrate-free diet while taking an SGLT2 inhibitor, there should be a low threshold to screen for DKA.
■我们描述了医院的课程,实验室数据,并对2例患者的治疗进行文献综述。
■我们发现两名患者的血糖水平正常或轻度升高,阴离子间隙升高和酮症,euDKA的代表。第一例患者仅服用1剂依帕列净后出现euDKA,而第二例患者在服用SGLT2抑制剂时仅服用生酮饮食1周后就出现了euDKA。
■虽然有一些关于使用SGLT2抑制剂和生酮饮食的euDKA的报道,许多开这些药物的医生可能没有意识到这种关联。因此,如果服用SGLT2抑制剂,他们必须告知患者避免生酮饮食.如果患者出现DKA症状,并且在服用SGLT2抑制剂的同时饮食不含碳水化合物,应该有一个低门槛来筛选DKA。