PDF(Pubmed)
Abstract：
The current knowledge regarding ADP-ribosylation modifications of histones, particularly mono-ADP-ribosylation modifications, is limited. However, recent studies have identified an increasing number of mono-ADP-ribosyltransferases and the role of mono-ADP-ribosylation has become a hot research topic. In particular, histones that are substrates of several mono-ADP-ribosyltransferases and mono-ADP-ribosylated histones were indicated to be involved in numerous physiological or pathological processes. Compared to poly-ADP-ribosylation histone modification, the use of mono-ADP-ribosylation histone modification is restricted by the limited methods for research into its function in physiological or pathological processes. The aim of the present review was to discuss the details regarding mono-ADP-ribosylation modification of histones and the currently known functions thereof, such as cell physiological and pathological processes, including tumorigenesis.
摘要：
关于组蛋白的ADP-核糖基化修饰的当前知识，特别是单ADP-核糖基化修饰，是有限的。然而,近年来研究发现越来越多的单ADP-核糖基转移酶,单ADP-核糖基转移酶的作用已成为研究热点。特别是,作为几种单ADP-核糖基转移酶和单ADP-核糖糖基化组蛋白的底物的组蛋白被表明参与许多生理或病理过程。与聚-ADP-核糖基化组蛋白修饰相比，单-ADP-核糖基化组蛋白修饰的使用受到用于研究其在生理或病理过程中的功能的有限方法的限制。本综述的目的是讨论关于组蛋白的单ADP核糖基化修饰及其目前已知的功能的细节，如细胞生理和病理过程，包括肿瘤发生。
