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Abstract：
Hepatoid thymic carcinoma is an extremely rare subtype of primary thymus tumor resembling \"pure\" hepatoid adenocarcinomas with hepatocyte paraffin 1 (Hep-Par-1) expression. A 53-year-old man presented with voice change and a neck mass. Multiple masses involving the thyroid, cervical and mediastinal lymph nodes, and lung were detected on computed tomography. Papillary thyroid carcinoma was confirmed by biopsy, and the patient underwent neoadjuvant chemoradiation therapy. However, the anterior mediastinal mass was enlarged after the treatment whereas the multiple masses in the thyroid and neck decreased in size. Microscopically, polygonal tumor cells formed solid sheets or trabeculae resembling hepatocytes and infiltrated remnant thymus. The tumor cells showed immunopositivity for cytokeratin 7, cytokeratin 19, and Hep-Par-1 and negativity for α-fetoprotein. Possibilities of germ cell tumor, squamous cell carcinoma, and metastasis of thyroid papillary carcinoma were excluded by immunohistochemistry. This report on the new subtype of thymic carcinoma is the third in English literature thus far.
摘要：
肝样胸腺癌是一种极为罕见的原发性胸腺肿瘤亚型，类似于“纯”肝样腺癌，具有肝细胞石蜡1（Hep-Par-1）表达。一名53岁的男子出现声音变化和颈部肿块。累及甲状腺的多个肿块,颈部和纵隔淋巴结，和肺在计算机断层扫描中检测到。甲状腺乳头状癌经活检证实，患者接受了新辅助放化疗。然而,治疗后纵隔前肿块扩大，而甲状腺和颈部的多发肿块缩小。微观上,多边形肿瘤细胞形成类似肝细胞的固体片或小梁和浸润的残余胸腺。肿瘤细胞对细胞角蛋白7，细胞角蛋白19和Hep-Par-1显示免疫阳性，对甲胎蛋白显示阴性。生殖细胞肿瘤的可能性，鳞状细胞癌,免疫组织化学排除甲状腺乳头状癌转移。迄今为止，有关胸腺癌新亚型的报道是英语文献中的第三篇。
