METHODS: The review is based on an electronic literature search performed in the PubMed database in September 2020 with the following key terms: eosinophilia & neoplasm; eosinophilia & cancer; eosinophilia & paraneoplastic syndrome. Papers were included based on screening the titles and/or abstracts. We also included the case of our patient in the analysis.
METHODS: A 68-year-old Caucasian female patient with recurrent CCRCC was admitted to our Clinic for exacerbating dyspnea and chest and right upper abdominal pain, accompanied by confusion. Preliminary blood tests showed an increased white blood cell count of 40,770/μl, and an increased eosinophil count of 6,530/μl indicating eosinophilia. Several tests were carried out to rule out the noncancer causes of hypereosinophilia. The temporal appearance of eosinophilia and the recurrence of CCRCC without any other apparent potential causes led to the diagnosis of paraneoplastic hypereosinophilia. Despite treating with high doses of corticosteroids, only a transient decrement in eosinophil count was observed along with further deterioration of the patient\'s condition. The patient succumbed to the disease 6 months following the tumor surgery and 2 months after the diagnosis of hypereosinophilia and tumor recurrence.
CONCLUSIONS: Our observations are in agreement with the majority of reports showing that the occurrence of eosinophilia following tumor resection may indicate a poor prognosis, tumor recurrence, and rapid disease progression.
方法:该综述基于2020年9月在PubMed数据库中进行的电子文献检索,其关键术语为:嗜酸性粒细胞增多和肿瘤;嗜酸性粒细胞增多和癌症;嗜酸性粒细胞增多和副肿瘤综合征。包括基于筛选标题和/或摘要的论文。我们还在分析中纳入了我们患者的病例。
方法:一名68岁的高加索女性患者因反复发作的CCRCC加重呼吸困难和胸部及右上腹痛而入院。伴随着混乱。初步血液检测显示白细胞计数增加40,770/μl,和6,530/μl的嗜酸性粒细胞计数增加,表明嗜酸性粒细胞增多。进行了几项测试以排除嗜酸性粒细胞增多的非癌症原因。嗜酸性粒细胞增多的暂时性出现和CCRCC的复发,没有任何其他明显的潜在原因,导致副肿瘤性嗜酸性粒细胞增多症的诊断。尽管使用高剂量的皮质类固醇治疗,仅观察到嗜酸性粒细胞计数短暂减少,同时患者病情进一步恶化。患者在肿瘤手术后6个月和诊断为嗜酸性粒细胞增多和肿瘤复发后2个月死于该疾病。
结论:我们的观察结果与大多数报告一致,这些报告表明肿瘤切除后嗜酸性粒细胞增多可能表明预后不良,肿瘤复发,和快速的疾病进展。