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Abstract：
The interrelation between glucose and bone metabolism is complex and has not been fully revealed. This study aimed to investigate the association between insulin resistance, β-cell function and bone turnover biomarker levels among participants with abnormal glycometabolism.
A total of 5277 subjects were involved through a cross-sectional study (METAL study, http://www.chictr.org.cn, ChiCTR1800017573) in Shanghai, China. Homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell dysfunction (HOMA-%β) were applied to elucidate the nexus between β-C-terminal telopeptide (β-CTX), intact N-terminal propeptide of type I collagen (P1NP) and osteocalcin (OC). β-CTX, OC and P1NP were detected by chemiluminescence.
HOMA-IR was negatively associated with β-CTX, P1NP and OC (regression coefficient (β) -0.044 (-0.053, -0.035), Q4vsQ1; β -7.340 (-9.130, -5.550), Q4vsQ1 and β -2.885 (-3.357, -2.412), Q4vsQ1, respectively, all P for trend <0.001). HOMA-%β was positively associated with β-CTX, P1NP and OC (β 0.022 (0.014, 0.031), Q4vsQ1; β 6.951 (5.300, 8.602), Q4vsQ1 and β 1.361 (0.921, 1.800), Q4vsQ1, respectively, all P for trend <0.001).
Our results support that lower bone turnover biomarker (β-CTX, P1NP and OC) levels were associated with a combination of higher prevalence of insulin resistance and worse β-cell function among dysglycemia patients. It is feasible to detect bone turnover in diabetes or hyperglycemia patients to predict the risk of osteoporosis and fracture, relieve patients\' pain and reduce the expenses of long-term cure.
A total of 5277 subjects were involved through a cross-sectional study (METAL study, http://www.chictr.org.cn, ChiCTR1800017573) in Shanghai, China. Homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell dysfunction (HOMA-%β) were applied to elucidate the nexus between β-C-terminal telopeptide (β-CTX), intact N-terminal propeptide of type I collagen (P1NP) and osteocalcin (OC). β-CTX, OC and P1NP were detected by chemiluminescence.
HOMA-IR was negatively associated with β-CTX, P1NP and OC (regression coefficient (β) -0.044 (-0.053, -0.035), Q4vsQ1; β -7.340 (-9.130, -5.550), Q4vsQ1 and β -2.885 (-3.357, -2.412), Q4vsQ1, respectively, all P for trend <0.001). HOMA-%β was positively associated with β-CTX, P1NP and OC (β 0.022 (0.014, 0.031), Q4vsQ1; β 6.951 (5.300, 8.602), Q4vsQ1 and β 1.361 (0.921, 1.800), Q4vsQ1, respectively, all P for trend <0.001).
Our results support that lower bone turnover biomarker (β-CTX, P1NP and OC) levels were associated with a combination of higher prevalence of insulin resistance and worse β-cell function among dysglycemia patients. It is feasible to detect bone turnover in diabetes or hyperglycemia patients to predict the risk of osteoporosis and fracture, relieve patients\' pain and reduce the expenses of long-term cure.
摘要：
葡萄糖与骨代谢之间的相互关系是复杂的，尚未完全揭示。本研究旨在探讨胰岛素抵抗与胰岛素抵抗之间的关系。糖代谢异常参与者的β细胞功能和骨转换生物标志物水平。
通过一项横断面研究，共涉及5277名受试者(金属研究，http://www。chictr.org.cn,ChiCTR1800017573)在上海，中国。胰岛素抵抗（HOMA-IR）和β细胞功能障碍（HOMA-%β）的稳态模型评估用于阐明β-C末端端肽（β-CTX）之间的联系，I型胶原（P1NP）和骨钙蛋白（OC）的完整N端前肽。β-CTX,化学发光法检测OC和P1NP。
HOMA-IR与β-CTX呈负相关,P1NP和OC（回归系数（β）-0.044（-0.053，-0.035），Q4vsQ1；β-7.340（-9.130，-5.550），Q4vsQ1和β-2.885（-3.357，-2.412），Q4vsQ1，分别，所有趋势P<0.001)。HOMA-%β与β-CTX呈正相关,P1NP和OC（β0.022（0.014，0.031），Q4vsQ1；β6.951（5.300，8.602），Q4vsQ1和β1.361（0.921，1.800），Q4vsQ1，分别，所有趋势P<0.001)。
我们的结果支持较低的骨转换生物标志物(β-CTX，在血糖异常患者中，P1NP和OC）水平与较高的胰岛素抵抗患病率和较差的β细胞功能有关。检测糖尿病或高血糖患者的骨转换来预测骨质疏松和骨折的风险是可行的。减轻患者的痛苦，减少长期治疗的费用。
通过一项横断面研究，共涉及5277名受试者(金属研究，http://www。chictr.org.cn,ChiCTR1800017573)在上海，中国。胰岛素抵抗（HOMA-IR）和β细胞功能障碍（HOMA-%β）的稳态模型评估用于阐明β-C末端端肽（β-CTX）之间的联系，I型胶原（P1NP）和骨钙蛋白（OC）的完整N端前肽。β-CTX,化学发光法检测OC和P1NP。
HOMA-IR与β-CTX呈负相关,P1NP和OC（回归系数（β）-0.044（-0.053，-0.035），Q4vsQ1；β-7.340（-9.130，-5.550），Q4vsQ1和β-2.885（-3.357，-2.412），Q4vsQ1，分别，所有趋势P<0.001)。HOMA-%β与β-CTX呈正相关,P1NP和OC（β0.022（0.014，0.031），Q4vsQ1；β6.951（5.300，8.602），Q4vsQ1和β1.361（0.921，1.800），Q4vsQ1，分别，所有趋势P<0.001)。
我们的结果支持较低的骨转换生物标志物(β-CTX，在血糖异常患者中，P1NP和OC）水平与较高的胰岛素抵抗患病率和较差的β细胞功能有关。检测糖尿病或高血糖患者的骨转换来预测骨质疏松和骨折的风险是可行的。减轻患者的痛苦，减少长期治疗的费用。
