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Abstract：
The treatments of nervous system diseases (NSDs) have long been difficult issues for researchers because of their complexity of pathogenesis. With the advent of aging society, searching for effective treatments of NSDs has become a hot topic. Ginseng polysaccharides (GP), as the main biologically active substance in ginseng, has various biological properties in immune-regulation, anti-oxidant, anti-inflammation and etc. Considering the association between the effects of GP and the pathogenesis of neurological disorders, many related experiments have been conducted in recent years. In this paper, we reviewed previous studies about the effects and mechanisms of GP on diseases related to nervous system. We found GP play an ameliorative role on NSDs through the regulation of immune system, inflammatory response, oxidative damage and signaling pathway. Structure-activity relationship was also discussed and summarized. In addition, we provided new insights into GP as promising neuroprotective agent for its further development and utilization.
摘要：
神经系统疾病(NSD)的治疗因其发病机制的复杂性一直是困扰研究者的难题。随着老龄化社会的到来,寻找NSD的有效治疗方法已成为热门话题。人参多糖（GP），作为人参中的主要生物活性物质，在免疫调节中具有各种生物学特性，抗氧化剂，抗炎等.考虑到GP的作用与神经系统疾病的发病机制之间的关联，近年来已经进行了许多相关的实验。在本文中,我们回顾了以往关于GP对神经系统相关疾病的影响和机制的研究。我们发现GP通过调节免疫系统对NSD发挥改善作用，炎症反应，氧化损伤和信号通路。并对构效关系进行了讨论和总结。此外,我们为GP作为有前途的神经保护剂的进一步开发和利用提供了新的见解。
