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Abstract：
Aging affects the serum levels of various metabolites which may be involved in the pathogenesis of chronic diseases. The aim of this review article is to summarize the relationship between aging and alterations in the plasma phospholipids and sphingomyelins.
PRISMA guidelines were employed during all steps. MEDLINE (PubMed), Scopus, Embase and Web of Sciences databases and Google Scholar were searched up to October 2020. Cohort studies investigating the relationship between aging and within-person changes in sphingomyelin (SM), phosphatidyl choline (PC), lyso PC (LPC) and phosphatidyl ethanolamine (PE) were included. Newcastle-Ottawa scale was used to assess the quality of included studies.
A total of 1425 studies were identified. After removing 610 duplicates and 723 irrelevant studies, full texts of 92 articles were evaluated. Of these 92, 6 studies (including data from 7 independent cohorts) met the inclusion criteria and are included in this review. All study populations were healthy and included both men and women. Results by sex were reported in 3 cohorts for PC, 5 cohorts for LPC, 3 cohorts for SM, and only 1 cohort for PE. In men, PC, SM, PE and LPC decreased with aging, although results for LPC were inconsistent. In women, LPC, SM, and PE increased age, whereas changes in PC were inconsistent.
Within-person serum levels of phospholipids and sphingomyelins, decrease during aging in men and increase in women. Notably, however, there were some inconsistencies across studies of LPC in men and of PC in women.
PRISMA guidelines were employed during all steps. MEDLINE (PubMed), Scopus, Embase and Web of Sciences databases and Google Scholar were searched up to October 2020. Cohort studies investigating the relationship between aging and within-person changes in sphingomyelin (SM), phosphatidyl choline (PC), lyso PC (LPC) and phosphatidyl ethanolamine (PE) were included. Newcastle-Ottawa scale was used to assess the quality of included studies.
A total of 1425 studies were identified. After removing 610 duplicates and 723 irrelevant studies, full texts of 92 articles were evaluated. Of these 92, 6 studies (including data from 7 independent cohorts) met the inclusion criteria and are included in this review. All study populations were healthy and included both men and women. Results by sex were reported in 3 cohorts for PC, 5 cohorts for LPC, 3 cohorts for SM, and only 1 cohort for PE. In men, PC, SM, PE and LPC decreased with aging, although results for LPC were inconsistent. In women, LPC, SM, and PE increased age, whereas changes in PC were inconsistent.
Within-person serum levels of phospholipids and sphingomyelins, decrease during aging in men and increase in women. Notably, however, there were some inconsistencies across studies of LPC in men and of PC in women.
摘要：
衰老会影响各种代谢产物的血清水平，这些代谢产物可能与慢性疾病的发病机理有关。这篇综述文章的目的是总结衰老与血浆磷脂和鞘磷脂改变之间的关系。
在所有步骤中使用PRISMA指南。MEDLINE(PubMed),Scopus,截至2020年10月，搜索了Embase和WebofSciences数据库以及GoogleScholar。队列研究调查衰老与人内鞘磷脂（SM）变化之间的关系，磷脂酰胆碱(PC),包括lysoPC(LPC)和磷脂酰乙醇胺(PE)。采用纽卡斯尔-渥太华量表评价纳入研究的质量。
总共确定了1425项研究。删除610个重复项和723个无关研究后，对92篇文章的全文进行了评估。在这92项研究中，6项研究（包括来自7个独立队列的数据）符合纳入标准，并被纳入本综述。所有研究人群都是健康的，包括男性和女性。按性别分列的结果在3个PC队列中报告，LPC的5个队列，SM的3个队列，只有1个队列为PE。在男人中，PC,SM,PE和LPC随老化而下降，尽管LPC的结果不一致。在女性中，LPC,SM,和体育年龄增加，而PC的变化不一致。
人体内血清磷脂和鞘磷脂水平，男性在衰老过程中减少，女性在衰老过程中增加。值得注意的是,然而,在男性LPC和女性PC的研究中存在一些不一致之处.
在所有步骤中使用PRISMA指南。MEDLINE(PubMed),Scopus,截至2020年10月，搜索了Embase和WebofSciences数据库以及GoogleScholar。队列研究调查衰老与人内鞘磷脂（SM）变化之间的关系，磷脂酰胆碱(PC),包括lysoPC(LPC)和磷脂酰乙醇胺(PE)。采用纽卡斯尔-渥太华量表评价纳入研究的质量。
总共确定了1425项研究。删除610个重复项和723个无关研究后，对92篇文章的全文进行了评估。在这92项研究中，6项研究（包括来自7个独立队列的数据）符合纳入标准，并被纳入本综述。所有研究人群都是健康的，包括男性和女性。按性别分列的结果在3个PC队列中报告，LPC的5个队列，SM的3个队列，只有1个队列为PE。在男人中，PC,SM,PE和LPC随老化而下降，尽管LPC的结果不一致。在女性中，LPC,SM,和体育年龄增加，而PC的变化不一致。
人体内血清磷脂和鞘磷脂水平，男性在衰老过程中减少，女性在衰老过程中增加。值得注意的是,然而,在男性LPC和女性PC的研究中存在一些不一致之处.
