PDF(Sci-hub)
Abstract：
Topographic maps, a key principle of brain organization, emerge during development. It remains unclear, however, whether topographic maps can represent a new sensory experience learned in adulthood. MaMe, a congenitally blind individual, has been extensively trained in adulthood for perception of a 2D auditory-space (soundscape) where the y- and x-axes are represented by pitch and time, respectively. Using population receptive field mapping we found neural populations tuned topographically to pitch, not only in the auditory cortices but also in the parietal and occipito-temporal cortices. Topographic neural tuning to time was revealed in the parietal and occipito-temporal cortices. Some of these maps were found to represent both axes concurrently, enabling MaMe to represent unique locations in the soundscape space. This case study provides proof of concept for the existence of topographic maps tuned to the newly learned soundscape dimensions. These results suggest that topographic maps can be adapted or recycled in adulthood to represent novel sensory experiences.
摘要：
地形图,大脑组织的关键原则，在发展过程中出现。目前还不清楚,然而,地形图是否可以代表成年后学到的新感官体验。MaMe,一个先天性失明的人，在成年期接受过广泛的训练，可以感知2D听觉空间（音景），其中y轴和x轴由音高和时间表示，分别。使用种群感受野作图，我们发现神经种群在地形上调整为音调，不仅在听觉皮层中，而且在顶叶和枕颞皮层中。在顶叶和枕颞皮质中发现了对时间的地形神经调整。发现其中一些地图同时代表两个轴，使MaMe能够代表音景空间中的独特位置。此案例研究为根据新学习的声景尺寸调整的地形图的存在提供了概念证明。这些结果表明，地形图可以在成年期进行调整或回收，以代表新颖的感官体验。
