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Abstract：
BACKGROUND: To investigate aqueous and lipid layers of the tear film as well as meibomian gland structure by meibography in psoriatic patients in the Iranian population.
METHODS: This case-control study was conducted on 31 psoriasis patients and 31 controls in Birjand University of Medical Sciences in 2018. The sampling method was available from the date of approval of the proposal in the Ethics Committee until it reached the sample size. After entering the study, patients were examined individually with a slit lamp. Then, Ocular Surface Disease Index (OSDI) score assessment, Schirmer test 1, lacrimal measurement with SM tube, tear break-up time (TBUT), and meibomian glands imaging by SBM Sistemi were done. Finally, the obtained data were entered into SPSS 15 software and analyzed at a significant level of less than 0.05.
RESULTS: The two groups were matched according to age and gender (p = 0.39 and p = 0.80; respectively). With the exception of the SM Tube score, the mean of all tear film and meibomian glands functional and structural parameters including Schirmer test 1, TBUT, and meibography were significantly different between patients and control groups. Moreover, the proportion of abnormal OSDI (OSDI ⩾ 13) and the dry eye was significantly higher in psoriasis patients.
CONCLUSIONS: Psoriasis is associated with dry eye as well as meibomian glands atrophy and dysfunction.
METHODS: This case-control study was conducted on 31 psoriasis patients and 31 controls in Birjand University of Medical Sciences in 2018. The sampling method was available from the date of approval of the proposal in the Ethics Committee until it reached the sample size. After entering the study, patients were examined individually with a slit lamp. Then, Ocular Surface Disease Index (OSDI) score assessment, Schirmer test 1, lacrimal measurement with SM tube, tear break-up time (TBUT), and meibomian glands imaging by SBM Sistemi were done. Finally, the obtained data were entered into SPSS 15 software and analyzed at a significant level of less than 0.05.
RESULTS: The two groups were matched according to age and gender (p = 0.39 and p = 0.80; respectively). With the exception of the SM Tube score, the mean of all tear film and meibomian glands functional and structural parameters including Schirmer test 1, TBUT, and meibography were significantly different between patients and control groups. Moreover, the proportion of abnormal OSDI (OSDI ⩾ 13) and the dry eye was significantly higher in psoriasis patients.
CONCLUSIONS: Psoriasis is associated with dry eye as well as meibomian glands atrophy and dysfunction.
摘要：
背景：在伊朗人群的银屑病患者中，通过囊图研究泪膜的水性和脂质层以及睑板腺结构。
方法：这项病例对照研究于2018年在比尔扬德医科大学对31名银屑病患者和31名对照进行。抽样方法从伦理委员会批准提案之日起，直至达到样本量。进入书房后,患者用裂隙灯单独检查。然后，眼表疾病指数（OSDI）评分评估，Schirmer试验1，用SM管测量泪管，泪液破裂时间(TBUT),通过SBMSistemi进行睑板腺成像。最后,将获得的数据输入SPSS15软件，并在小于0.05的显著水平进行分析。
结果：两组根据年龄和性别进行匹配（分别为p=0.39和p=0.80）。除了SM管评分,所有泪膜和睑板腺功能和结构参数的平均值，包括Schirmer试验1，TBUT，两组患者和对照组之间存在显著差异。此外，银屑病患者OSDI异常(OSDI13)和干眼症的比例明显较高.
结论：银屑病与干眼以及睑板腺萎缩和功能障碍有关。
方法：这项病例对照研究于2018年在比尔扬德医科大学对31名银屑病患者和31名对照进行。抽样方法从伦理委员会批准提案之日起，直至达到样本量。进入书房后,患者用裂隙灯单独检查。然后，眼表疾病指数（OSDI）评分评估，Schirmer试验1，用SM管测量泪管，泪液破裂时间(TBUT),通过SBMSistemi进行睑板腺成像。最后,将获得的数据输入SPSS15软件，并在小于0.05的显著水平进行分析。
结果：两组根据年龄和性别进行匹配（分别为p=0.39和p=0.80）。除了SM管评分,所有泪膜和睑板腺功能和结构参数的平均值，包括Schirmer试验1，TBUT，两组患者和对照组之间存在显著差异。此外，银屑病患者OSDI异常(OSDI13)和干眼症的比例明显较高.
结论：银屑病与干眼以及睑板腺萎缩和功能障碍有关。
