Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea During Treatment: A Case Report and Literature Review.

治疗期间以 T 滤泡辅助表型表现为舞蹈症的淋巴结外周 T 细胞淋巴瘤 1 例报告并文献复习 [J].

• 影响指数: 1.282
• 发表时间: Oct 2021 1
• 来源期刊: Intern Med
• DOI: 10.2169/internalmedicine.7180-21
• PMID: 33814503
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Kitamura W,Ennishi D,Yukawa R,Sasaki R,Yoshida C,Takasuka H,Fujiwara H,Asada N,Nishimori H,Fujii K,Fujii N,Matsuoka KI,Abe K,Yoshino T,Maeda Y

关键词: chorea; peripheral T-cell lymphoma; single photon-emission computed tomography

Mesh: Aged; Brain; Cerebrovascular Circulation; Chorea / diagnostic imaging etiology; Humans; Iofetamine; Lymphoma, T-Cell, Peripheral; Male; Neoplasm Recurrence, Local; Phenotype; T-Lymphocytes, Helper-Inducer; Tomography, Emission-Computed, Single-Photon

Abstract

A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-p-iodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients.

摘要

一名72岁的男子在接受具有T滤泡辅助细胞（TFH）表型的结节性外周T细胞淋巴瘤复发治疗时出现舞蹈病。通过脑部N-异丙基-对碘苯丙胺（123I-IMP）-单光子发射计算机断层扫描（SPECT）进行的检查显示，除了左纹状体的脑血流量（CBF）减少外，没有其他异常。经过四个疗程的挽救性化疗，他的临床症状和不对称的脑灌注得到改善，提示CBF降低导致了舞蹈病.脑SPECT在舞蹈相关恶性淋巴瘤患者中的意义尚未完全阐明，保证进一步调查。脑SPECT是识别此类患者异常的替代方法。