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Abstract：
Ophthalmic drugs used for the treatment of various ocular diseases are commonly administered by eye drops. However, due to anatomical and physiological factors, there is a low bioavailability of the active principle. In order to increase the drug residence time on the cornea to adequate levels, therapeutic contact lenses have recently been proposed. The polymeric support that constitutes the contact lens is loaded with the drug; in this way, there is a direct and effective pharmacological action on the target organ, promoting a prolonged release of the active principle. The incorporation of ophthalmic drugs into contact lenses can be performed by different techniques; nowadays, the soaking method is mainly employed. To improve the therapeutic performance of drug-loaded contact lenses, innovative methods have recently been proposed, including the impregnation with supercritical carbon dioxide. This updated review of therapeutic contact lenses production and application provides useful information on the most effective preparation methodologies, recent achievements and future perspectives.
摘要：
用于治疗各种眼部疾病的眼科药物通常通过滴眼剂给药。然而,由于解剖和生理因素，活性成分的生物利用度较低。为了将药物在角膜上的停留时间增加到足够的水平，最近已经提出了治疗性隐形眼镜。构成隐形眼镜的聚合物载体装载有药物；以这种方式，对靶器官有直接有效的药理作用，促进活性成分的延长释放。将眼用药物掺入隐形眼镜可以通过不同的技术进行；如今，主要采用浸泡法。为了提高载药隐形眼镜的治疗性能，最近提出了创新的方法，包括超临界二氧化碳的浸渍。对治疗性隐形眼镜生产和应用的最新审查提供了有关最有效制备方法的有用信息，最近的成就和未来的前景。
