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Abstract：
Insulin resistance (IR) is defined as a lower-than-expected response to insulin action from target tissues, leading to the development of type 2 diabetes through the impairment of both glucose and lipid metabolism. IR is a common condition in subjects with nonalcoholic fatty liver disease (NAFLD) and is considered one of the main factors involved in the pathogenesis of nonalcoholic steatohepatitis (NASH) and in the progression of liver disease. The liver, the adipose tissue and the skeletal muscle are major contributors for the development and worsening of IR. In this review, we discuss the sites and mechanisms of insulin action and the IR-related impairment along the spectrum of NAFLD, from simple steatosis to progressive NASH and cirrhosis.
摘要：
胰岛素抵抗（IR）被定义为对靶组织的胰岛素作用的反应低于预期，通过损害糖脂代谢导致2型糖尿病的发展。IR是非酒精性脂肪性肝病（NAFLD）患者的常见病，被认为是非酒精性脂肪性肝炎（NASH）发病机理和肝病进展的主要因素之一。肝脏，脂肪组织和骨骼肌是IR发生和恶化的主要因素。在这次审查中,我们讨论了胰岛素作用的位点和机制以及沿着NAFLD谱的IR相关损伤，从简单的脂肪变性到进行性NASH和肝硬化。
