关键词: acute myeloid leukemia arginine deprivation low-dose cytarabine pegylated arginine deiminase (ADI-PEG20) phase I
Mesh : Adult Aged Aged, 80 and over Anemia / chemically induced Antineoplastic Combined Chemotherapy Protocols / administration & dosage adverse effects pharmacokinetics Arginine / drug effects metabolism Argininosuccinate Synthase / deficiency Cytarabine / administration & dosage adverse effects pharmacokinetics Drug Administration Schedule Female Humans Hydrolases / administration & dosage adverse effects pharmacokinetics Injections, Intramuscular Injections, Subcutaneous Leukemia, Myeloid, Acute / drug therapy enzymology metabolism mortality Male Maximum Tolerated Dose Middle Aged Neutropenia / chemically induced Polyethylene Glycols / administration & dosage adverse effects pharmacokinetics Thrombocytopenia / chemically induced Treatment Outcome
来 源:
DOI:10.1002/cam4.3871
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