Isorhapontigin 通过增加 YAP1 表达来保护多柔比星诱导的心脏毒性。
关键词: AMPK, AMP-activated protein kinase AP-1, anti-microbial protein AREG, amphiregulin AUC/Dose, dose-normalized plasma exposures Amphiregulin Ang II, angiotensin II CO, cardiac output CTGF, connective tissue growth factor Cardiomyocytes apoptosis Cardiotoxicity Cmax/Dose, dose-normalized maximal plasma concentrations Connective tissue growth factor DAB, 3,3′-diaminobenzidine DMEM, Dulbecco's modified Eagle's medium Dob, dobutamine Dox, doxorubicin Doxorubicin EMT, epithelial mesenchymal transformation FOXO1, forkhead box class O1 FS, fractional shortening HE, hematoxylin–eosin ISO, isoproterenol Isor, isorhapontigenin Isorhapontigenin LVAW;d, left ventricular end-diastolic anterior wall thickness LVAW;s, left ventricular end-systolic anterior wall thickness LVEF, left ventricular ejection fraction LVID;d, left ventricular end-diastolic internal diameter LVID;s, left ventricular end-systolic internal diameter LVPW;d, left ventricular end-diastolic posterior wall thickness LVPW;s, left ventricular end-systolic posterior wall thickness MAPK, mitogen-activated protein kinase MI, myocardial infarction NF-κB, nuclear factor kappa-B NRCMs, neonatal rat cardiomyocytes P2Y12 receptor, ADP receptor PGC-1α, peroxisome proliferator-activated receptor γ coactivator-1α PMSF, phenylmethanesulfonyl fluoride PVDF, polyvinylidene fluoride ROS, reactive oxygen species SD, Sprague–Dawley SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis SESN2, sestrin2 TCF4, T-cell factor 4 TEAD, TEA domain transcription factor proteins TEAD1 TUNEL, TdT-mediated dUTP nick end labeling WGA, wheat germ agglutinin YAP1 YAP1, Yes-associated protein 1 qRT-PCR, quantitative real-time polymerase chain reaction sgRNAs, sequence guiding RNAs Δψm, mitochondrial membrane potential
来 源:
DOI:10.1016/j.apsb.2020.10.017
PDF(Sci-hub)
PDF(Pubmed)