PDF(Pubmed)
Abstract：
While age-related changes in menstrual cycle length are well known, it is unclear whether anti-Müllerian (AMH) or other ovarian reserve biomarkers have a direct association with cycle length.
To determine the association between biomarkers of ovarian reserve and menstrual cycle length.
Secondary analysis using data from time to conceive (TTC), a prospective time to pregnancy cohort study. The age-independent association between cycle length and biomarkers of ovarian reserve was analyzed using linear mixed and marginal models. Study participants were TTC-enrolled women aged 30-44 years with no history of infertility who were attempting to conceive for <3 months were enrolled. Serum AMH, follicle-stimulating hormone, and inhibin B levels were measured on cycle day 2, 3, or 4. Participants recorded daily menstrual cycle data for ≤4 months. The primary outcome was menstrual cycle length; follicular and luteal phase lengths were secondary outcomes.
Multivariable analysis included 1880 cycles from 632 women. Compared with AMH levels of 1.6 to 3.4 ng/mL, women with AMH <1.6 ng/mL had cycles and follicular phases that were 0.98 (95% CI -1.46, -0.50) and 1.58 days shorter (95% CI -2.53, -0.63), respectively, while women with AMH >8 ng/mL had cycles that were 2.15 days longer (95% CI 1.46, 2.83), follicular phases that were 2 days longer (95% CI 0.77, 3.24), and luteal phases that were 1.80 days longer (95% CI 0.71, 2.88).
Increasing AMH levels are associated with longer menstrual cycles due to both a lengthening of the follicular and the luteal phase independent of age.
To determine the association between biomarkers of ovarian reserve and menstrual cycle length.
Secondary analysis using data from time to conceive (TTC), a prospective time to pregnancy cohort study. The age-independent association between cycle length and biomarkers of ovarian reserve was analyzed using linear mixed and marginal models. Study participants were TTC-enrolled women aged 30-44 years with no history of infertility who were attempting to conceive for <3 months were enrolled. Serum AMH, follicle-stimulating hormone, and inhibin B levels were measured on cycle day 2, 3, or 4. Participants recorded daily menstrual cycle data for ≤4 months. The primary outcome was menstrual cycle length; follicular and luteal phase lengths were secondary outcomes.
Multivariable analysis included 1880 cycles from 632 women. Compared with AMH levels of 1.6 to 3.4 ng/mL, women with AMH <1.6 ng/mL had cycles and follicular phases that were 0.98 (95% CI -1.46, -0.50) and 1.58 days shorter (95% CI -2.53, -0.63), respectively, while women with AMH >8 ng/mL had cycles that were 2.15 days longer (95% CI 1.46, 2.83), follicular phases that were 2 days longer (95% CI 0.77, 3.24), and luteal phases that were 1.80 days longer (95% CI 0.71, 2.88).
Increasing AMH levels are associated with longer menstrual cycles due to both a lengthening of the follicular and the luteal phase independent of age.
摘要：
虽然月经周期长度与年龄相关的变化是众所周知的，目前尚不清楚抗苗勒管(AMH)或其他卵巢储备生物标志物是否与周期长度直接相关.
确定卵巢储备生物标志物与月经周期长度之间的关联。
使用受孕时间(TTC)数据进行二次分析，一项前瞻性妊娠时间队列研究。使用线性混合模型和边缘模型分析了周期长度与卵巢储备生物标志物之间的年龄无关性关联。研究参与者是TTC招募的30-44岁女性，没有不孕史，试图怀孕<3个月。血清AMH,促卵泡激素,在第2、3或4个周期测量抑制素B水平。参与者记录≤4个月的每日月经周期数据。主要结果是月经周期长度；卵泡和黄体期长度是次要结果。
多变量分析包括632名女性的1880个周期。与1.6至3.4ng/mL的AMH水平相比，AMH<1.6ng/mL的女性周期和卵泡期分别为0.98天(95%CI-1.46,-0.50)和1.58天(95%CI-2.53,-0.63),分别,而AMH>8ng/mL的女性周期延长2.15天（95%CI1.46,2.83），延长2天的卵泡期（95％CI0.77，3.24），和黄体期延长1.80天(95%CI0.71,2.88)。
AMH水平的增加与月经周期的延长有关，这是因为卵泡和黄体期的延长与年龄无关。
确定卵巢储备生物标志物与月经周期长度之间的关联。
使用受孕时间(TTC)数据进行二次分析，一项前瞻性妊娠时间队列研究。使用线性混合模型和边缘模型分析了周期长度与卵巢储备生物标志物之间的年龄无关性关联。研究参与者是TTC招募的30-44岁女性，没有不孕史，试图怀孕<3个月。血清AMH,促卵泡激素,在第2、3或4个周期测量抑制素B水平。参与者记录≤4个月的每日月经周期数据。主要结果是月经周期长度；卵泡和黄体期长度是次要结果。
多变量分析包括632名女性的1880个周期。与1.6至3.4ng/mL的AMH水平相比，AMH<1.6ng/mL的女性周期和卵泡期分别为0.98天(95%CI-1.46,-0.50)和1.58天(95%CI-2.53,-0.63),分别,而AMH>8ng/mL的女性周期延长2.15天（95%CI1.46,2.83），延长2天的卵泡期（95％CI0.77，3.24），和黄体期延长1.80天(95%CI0.71,2.88)。
AMH水平的增加与月经周期的延长有关，这是因为卵泡和黄体期的延长与年龄无关。
