Abstract：
The luminal gastrointestinal tract can be a site of robust immune response in which reactive lymphoproliferative processes can sometimes be difficult to distinguish from lymphoma. In this article, we review gastrointestinal tract normal resident inflammatory cells and common nonneoplastic lymphoproliferative responses with emphasis on their differential and links to lymphoma. Topics that are covered include lymphocytic esophagitis, gastric chronic inflammation, mucosa-associated lymphoid tissue, and ulceration, small intestinal lymphoid hyperplasia, celiac disease, microscopic colitis, inflammatory bowel disease, primary immunodeficiency, graft-versus-host disease, and anti-programmed cell death protein-1 effect. We additionally present the less common differential of histiocytic processes within the gastrointestinal tract. The aim of this paper is to serve as a reference for practicing pathologists facing lymphoid, lymphoplasmacytic, or histiocytic processes in the luminal gastrointestinal tract. We hope to help the practicing pathologist distinguish benign from malignant entities and identify features requiring further workup.
摘要：
腔胃肠道可能是强烈免疫反应的部位，其中反应性淋巴增生过程有时很难与淋巴瘤区分开。在这篇文章中,我们回顾了胃肠道正常的常驻炎症细胞和常见的非肿瘤性淋巴增生反应，重点是它们的差异和与淋巴瘤的联系。涵盖的主题包括淋巴细胞性食管炎，胃慢性炎症，粘膜相关淋巴组织，和溃疡，小肠淋巴增生,乳糜泻,显微镜下结肠炎,炎症性肠病，原发性免疫缺陷,移植物抗宿主病,和抗程序性细胞死亡蛋白-1效应。我们还提出了胃肠道内组织细胞过程不太常见的差异。本文的目的是为实践面对淋巴的病理学家提供参考。淋巴浆细胞，或腔胃肠道中的组织细胞过程。我们希望帮助执业病理学家区分良性和恶性实体，并确定需要进一步检查的特征。
