PDF(Pubmed)
Abstract：
UNASSIGNED: Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, considerable attention has been paid on its epidemiology and clinical characteristics in children patients. However, it is also crucial for clinicians to summarize and investigate the co-infection of SARS-CoV-2 in children.We retrospectively reviewed the clinical manifestations, laboratory findings, and imaging characteristics of COVID-19 patients in co-infection group (CI, n = 27) and single infection group (SI, n = 54). Samples were tested for multiple pathogens.A high incidence (27/81, 33%) of co-infection in children with COVID-19 was revealed. The most frequent co-infected pathogen was mycoplasma pneumoniae (MP, 20/81, 25%), followed by virus (6/81, 7%), and bacteria (4/81, 5%). No significant difference in clinical characteristics, laboratory examinations, or hospital stay was observed between the patients with co-infections and those with monomicrobial, only lower in white blood cell counts (CI: 5.54 ± 0.36 vs SI: 7.38 ± 0.37, P = .002), neutrophil counts (CI: 2.20 ± 0.20 vs SI: 2.92 ± 0.23, P = .024) and lymphocyte counts (CI: 2.72 ± 0.024 vs SI: 3.87 ± 0.28, P = .006). Compared with the patients with monomicrobial, chest imaging of those with co-infections showed consolidation in more cases (CI: 29.6% vs SI: 11.1%, P = .038) and duration of positive in nucleic acid was shorter (CI: 6.69 ± 0.82 vs SI: 9.69 ± 0.74, P = .015).Co-infection was relatively common in children with COVID-19, almost 1/3 had co-infection, most commonly caused by MP. Co-infection did not cause a significant exacerbation in clinical manifestations.
摘要：
未经批准：自2019年武汉冠状病毒病（COVID-19）爆发以来，其在儿童患者中的流行病学和临床特征受到了广泛的关注。然而,临床医生总结和调查SARS-CoV-2在儿童中的合并感染也至关重要。我们回顾了临床表现，实验室发现,合并感染组（CI，n=27）和单一感染组（SI，n=54）。测试样品的多种病原体。发现COVID-19儿童共感染的发生率很高（27/81，33%）。最常见的共感染病原体是肺炎支原体（MP，20/81，25%），其次是病毒(6/81，7%)，和细菌(4/81，5%)。临床特征无显著差异，实验室检查,或住院时间在合并感染患者和单抗菌药患者之间观察，白细胞计数仅较低（CI：5.54±0.36vsSI：7.38±0.37，P=0.002），中性粒细胞计数（CI：2.20±0.20vsSI：2.92±0.23，P=.024）和淋巴细胞计数（CI：2.72±0.024vsSI：3.87±0.28，P=.006）。与单抗菌药患者相比，合并感染的患者的胸部影像学显示在更多病例中巩固（CI：29.6％vsSI：11.1％，P=.038），核酸阳性持续时间较短（CI：6.69±0.82vsSI：9.69±0.74，P=.015）。合并感染在COVID-19患儿中相对常见，近1/3合并感染，最常见的原因是MP。共感染并未引起临床表现的明显恶化。
