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Abstract：
The most important health benefit of selenium (Se) is in the prevention and control of cancer. Glutathione peroxidases (GPXs) and thioredoxin reductases (TXNRDs) are selenoenzymes that are thought to play a role in oxidative stress. The differential expression of genes of the TXNRD and GPX families is closely related to carcinogenesis and the occurrence of cancer. This study comprehensively analyzed the expression profiles of seven genes in the TXNRD and GPX families, in terms of their correlations with patient survival and immune-cell subtypes, tumor microenvironment, and drug sensitivity.
The expression profiles of genes in the TXNRD and GPX families differ between different types of cancer, and also between and within individual cancer cases. The expression levels of the seven analyzed genes are related to the overall survival of patients. The TXNRD1 and TXNRD3 genes are mainly related to poor prognoses, while other genes are related to good or poor prognoses depending on the type of cancer. All of the genes were found to be correlated to varying degrees with immune-cell subtypes, level of mechanistic cell infiltration, and tumor cell stemness. The TXNRD1, GPX1, and GPX2 genes may exert dual effects in tumor mutagenesis and development, while the TXNRD1, GPX1, GPX2, and GPX3 genes were found to be related to drug sensitivity or the formation of drug resistance.
The results will greatly help in identifying the association between genes and tumorigenesis, especially in the immune response, tumor microenvironment, and drug resistance, and very important when attempting to identify new therapeutic targets.
The expression profiles of genes in the TXNRD and GPX families differ between different types of cancer, and also between and within individual cancer cases. The expression levels of the seven analyzed genes are related to the overall survival of patients. The TXNRD1 and TXNRD3 genes are mainly related to poor prognoses, while other genes are related to good or poor prognoses depending on the type of cancer. All of the genes were found to be correlated to varying degrees with immune-cell subtypes, level of mechanistic cell infiltration, and tumor cell stemness. The TXNRD1, GPX1, and GPX2 genes may exert dual effects in tumor mutagenesis and development, while the TXNRD1, GPX1, GPX2, and GPX3 genes were found to be related to drug sensitivity or the formation of drug resistance.
The results will greatly help in identifying the association between genes and tumorigenesis, especially in the immune response, tumor microenvironment, and drug resistance, and very important when attempting to identify new therapeutic targets.
摘要：
硒（Se）最重要的健康益处是预防和控制癌症。谷胱甘肽过氧化物酶（GPXs）和硫氧还蛋白还原酶（TXNRD）是硒酶，被认为在氧化应激中起作用。TXNRD和GPX家族基因的差异表达与肿瘤的发生和发生密切相关。本研究综合分析了TXNRD和GPX家族中7个基因的表达谱,就它们与患者生存和免疫细胞亚型的相关性而言，肿瘤微环境,和药物敏感性。
TXNRD和GPX家族的基因表达谱在不同类型的癌症之间存在差异，以及个别癌症病例之间和内部。所分析的7个基因的表达水平与患者的总体存活相关。TXNRD1和TXNRD3基因主要与不良预后有关，而其他基因与预后的好坏有关，具体取决于癌症的类型。发现所有基因都与免疫细胞亚型有不同程度的相关性，机械性细胞浸润水平，和肿瘤细胞的干细胞。TXNRD1，GPX1和GPX2基因可能在肿瘤的诱变和发展中发挥双重作用。而TXNRD1、GPX1、GPX2和GPX3基因被发现与药物敏感性或耐药性的形成有关。
这些结果将大大有助于确定基因与肿瘤发生之间的关联，尤其是在免疫反应中，肿瘤微环境,和抗药性，在试图确定新的治疗靶点时非常重要。
TXNRD和GPX家族的基因表达谱在不同类型的癌症之间存在差异，以及个别癌症病例之间和内部。所分析的7个基因的表达水平与患者的总体存活相关。TXNRD1和TXNRD3基因主要与不良预后有关，而其他基因与预后的好坏有关，具体取决于癌症的类型。发现所有基因都与免疫细胞亚型有不同程度的相关性，机械性细胞浸润水平，和肿瘤细胞的干细胞。TXNRD1，GPX1和GPX2基因可能在肿瘤的诱变和发展中发挥双重作用。而TXNRD1、GPX1、GPX2和GPX3基因被发现与药物敏感性或耐药性的形成有关。
这些结果将大大有助于确定基因与肿瘤发生之间的关联，尤其是在免疫反应中，肿瘤微环境,和抗药性，在试图确定新的治疗靶点时非常重要。
