UNASSIGNED: One hundred and one HSCT recipients (37 prospective and 64 retrospective) were followed up for hepatobiliary dysfunction in the post-transplant period. The causes for hepatobiliary dysfunction were categorized as sinusoidal obstruction syndrome (SOS), formerly known as veno-occlusive disease (VOD); acute and chronic graft-versus- host disease (GVHD); drug-induced liver injury (DILI); viral infections and miscellaneous causes including bacterial, fungal and unknown causes based on clinical and laboratory evidence.
UNASSIGNED: Among the 101 transplants, 56.44% (n = 57) were allogenic transplants, and 43.56% (n = 44) were autologous transplants. Hepatobiliary dysfunction was observed among 71 (70.30%) patients in first 30 days and overall, among 78 (77.23%) patients. Incidence of hepatobiliary dysfunction was higher among allogenic transplant patients compared to autologous transplants (91.23% vs. 59.09%, p < 0.001). The most common cause of hepatobiliary dysfunction reported was Drug-induced liver injury (DILI). In most cases, however, hepatobiliary dysfunction was multifactorial. Sinusoidal obstruction syndrome (15.79%), acute liver GVHD (31.58%), chronic liver GVHD (33.33%) and viral infection/reactivation (26.32%) were reported only in allogenic transplant patients. 15 (14.85%) patients died of which 14 patients had hepatobiliary dysfunction, commonest cause being infections.
UNASSIGNED: Our study reported a higher incidence of hepatobiliary dysfunction among Indian population post HSCT and was associated with significant mortality. In majority of the cases, the cause is multifactorial and pose a diagnostic dilemma and challenges in therapy.
■在移植后期间,对101例HSCT接受者(37例前瞻性和64例回顾性)进行了肝胆功能障碍随访。肝胆功能障碍的原因被归类为正弦阻塞综合征(SOS),以前称为静脉闭塞性疾病(VOD);急性和慢性移植物抗宿主病(GVHD);药物性肝损伤(DILI);病毒感染和其他原因,包括细菌,基于临床和实验室证据的真菌和未知原因。
■在101例移植中,56.44%(n=57)是同种异体移植,43.56%(n=44)为自体移植。在前30天和总体上,在71例(70.30%)患者中观察到肝胆功能障碍。78例(77.23%)患者。与自体移植相比,同种异体移植患者肝胆功能障碍的发生率更高(91.23%vs.59.09%,p<0.001)。据报道,肝胆功能障碍的最常见原因是药物性肝损伤(DILI)。在大多数情况下,然而,肝胆功能障碍是多因素的。窦性阻塞综合征(15.79%),急性肝GVHD(31.58%),仅在同种异体移植患者中报告了慢性肝GVHD(33.33%)和病毒感染/再激活(26.32%).15例(14.85%)患者死亡,其中14例患者有肝胆功能障碍,最常见的原因是感染。
■我们的研究报告,在HSCT后的印度人群中,肝胆功能障碍的发生率较高,并且与显著的死亡率相关。在大多数情况下,病因是多因素的,在治疗中带来了诊断困境和挑战.