将毒素靶向肿瘤。
关键词: ADC ADEPT GDEPT LEAPT PROTAC chemotherapy drug targeting overexpressed enzymes prodrug
Mesh : Antineoplastic Agents / chemistry pharmacology Apoptosis / drug effects Calicheamicins / pharmacology Cell Proliferation / drug effects Delayed-Action Preparations / chemistry Drug Carriers / chemistry Drug Design Drug Liberation Enzyme Therapy Gene Knockdown Techniques Humans Lung Neoplasms / drug therapy Male Maytansine / pharmacology Molecular Targeted Therapy Peptide Hydrolases / genetics metabolism Prodrugs / chemistry pharmacology Prostatic Neoplasms / drug therapy Thapsigargin / pharmacology Toxins, Biological / chemistry pharmacology
来 源:
DOI:10.3390/molecules26051292
PDF(Sci-hub)
PDF(Pubmed)