关键词: botulinum toxin A facial asymmetry facial palsy facial paralysis incobotulinum-toxin A neurotoxin

Mesh : Acetylcholine Release Inhibitors / administration & dosage adverse effects Adult Bell Palsy / diagnosis drug therapy physiopathology Botulinum Toxins, Type A / administration & dosage adverse effects Facial Muscles / drug effects physiopathology Facial Paralysis / diagnosis drug therapy physiopathology Female Humans Injections, Intramuscular Quality of Life Treatment Outcome

来  源:   DOI:10.3390/toxins13020159   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Unilateral peripheral facial nerve palsy jeopardizes quality of life, rendering psychological consequences such as low self-esteem, social isolation, anxiety, and depression. Among therapeutical approaches, use of Botulinum toxin type A (BoNT-A) on the nonparalyzed side has shown promising results and improvement of quality of life. Nevertheless, the correct technique is paramount, since over-injection of the muscles can result in lack of function, leading to a \"paralyzed\" appearance, and even worse, functional incompetence, which may cause greater distress to patients. Therefore, the objective of this article is to provide a practical guideline for botulinum toxin use in facial palsy. To this aim, adequate patient assessment, BoNT-A choice, injection plan and dosage, and injection techniques are covered.
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