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Abstract：
BACKGROUND: Schistosomiasis is a highly prevalent parasitic disease that can lead to adverse maternal and perinatal outcomes. To our knowledge, there has been no systematic review and meta-analysis of schistosomiasis during pregnancy.
METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant published studies were searched in international databases (PubMed, Science Direct, Scopus, Web of Science, and Google Scholar), from their inception until May 31, 2020. The retrieved studies were assessed for quality using the Modified Newcastle-Ottawa Scale. OpenMeta Analyst software was used for the statistical analysis.
RESULTS: Thirty-two studies enrolling 21024 pregnant women were included in this meta-analysis. All 32 of these studies were conducted in Africa. Of these studies, 19, 11, and 2 investigated S. mansoni, S. haematobium, and combined S. mansoni and S. haematobium infections, respectively. The pooled prevalence estimate of schistosomiasis during pregnancy was 13.2% (95 CI 11.0-15.4). A random model was used because of high heterogeneity (Q = 99.14; P < 0.001). In subgroup analyses, the pooled prevalence estimate of S. haematobium was significantly higher than the pooled prevalence estimates of S. mansoni [22.5% (95% CI 1.6-43.5) vs 8.7% (95% CI 6.0-11.3, P = 0.016), respectively]. The results of meta-regression analyses showed a non-significant difference in the prevalence of schistosomiasis during pregnancy according to the study sample sizes and year of publication. Only six studies evaluated the association between schistosomiasis during pregnancy and anemia. Schistosomiasis was associated with anemia in these six studies (OR = 3.02, 95% = 1.25‒7.28, P = 0.014).
CONCLUSIONS: The present meta-analysis suggests that schistosomiasis during pregnancy is an existing health problem. This meta-analysis also highlights the lack of data on the determinants and outcomes of schistosomiasis during pregnancy. Preventive measures are needed and could be part of antenatal care in areas endemic with schistosomiasis.
METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant published studies were searched in international databases (PubMed, Science Direct, Scopus, Web of Science, and Google Scholar), from their inception until May 31, 2020. The retrieved studies were assessed for quality using the Modified Newcastle-Ottawa Scale. OpenMeta Analyst software was used for the statistical analysis.
RESULTS: Thirty-two studies enrolling 21024 pregnant women were included in this meta-analysis. All 32 of these studies were conducted in Africa. Of these studies, 19, 11, and 2 investigated S. mansoni, S. haematobium, and combined S. mansoni and S. haematobium infections, respectively. The pooled prevalence estimate of schistosomiasis during pregnancy was 13.2% (95 CI 11.0-15.4). A random model was used because of high heterogeneity (Q = 99.14; P < 0.001). In subgroup analyses, the pooled prevalence estimate of S. haematobium was significantly higher than the pooled prevalence estimates of S. mansoni [22.5% (95% CI 1.6-43.5) vs 8.7% (95% CI 6.0-11.3, P = 0.016), respectively]. The results of meta-regression analyses showed a non-significant difference in the prevalence of schistosomiasis during pregnancy according to the study sample sizes and year of publication. Only six studies evaluated the association between schistosomiasis during pregnancy and anemia. Schistosomiasis was associated with anemia in these six studies (OR = 3.02, 95% = 1.25‒7.28, P = 0.014).
CONCLUSIONS: The present meta-analysis suggests that schistosomiasis during pregnancy is an existing health problem. This meta-analysis also highlights the lack of data on the determinants and outcomes of schistosomiasis during pregnancy. Preventive measures are needed and could be part of antenatal care in areas endemic with schistosomiasis.
摘要：
背景：血吸虫病是一种高度流行的寄生虫病，可导致不良的母体和围产期结局。据我们所知,尚未对妊娠期血吸虫病进行系统评价和荟萃分析.
方法：我们遵循系统评价和荟萃分析指南的首选报告项目。在国际数据库(PubMed，科学直接，Scopus,WebofScience,和谷歌学者)，从成立到2020年5月31日。使用改良的纽卡斯尔-渥太华量表对检索到的研究进行质量评估。采用OpenMetaAnalyst软件进行统计分析。
结果：这项荟萃分析纳入了32项纳入21024名孕妇的研究。所有32项研究都是在非洲进行的。在这些研究中,19、11和2调查了S.Mansoni，S、嗜血杆菌，结合曼氏链球菌和埃博拉链球菌感染，分别。妊娠期血吸虫病的合并患病率估计为13.2%(95CI11.0-15.4)。由于高度异质性(Q=99.14;P<0.001),使用随机模型。在亚组分析中，合并的血吸虫流行率估计值显著高于合并的曼氏血吸虫流行率估计值[22.5%(95%CI1.6-43.5)对8.7%(95%CI6.0-11.3,P=0.016),分别]。荟萃回归分析结果显示，根据研究样本量和发表年份，妊娠期血吸虫病患病率无显著差异。只有6项研究评估了妊娠期血吸虫病与贫血之间的关系。6项研究中血吸虫病与贫血相关(OR=3.02,95%=1.25~7.28,P=0.014)。
结论：本荟萃分析提示妊娠期血吸虫病是一个现存的健康问题。这项荟萃分析还强调了缺乏有关怀孕期间血吸虫病的决定因素和结局的数据。在血吸虫病流行地区，需要采取预防措施，并可能成为产前护理的一部分。
方法：我们遵循系统评价和荟萃分析指南的首选报告项目。在国际数据库(PubMed，科学直接，Scopus,WebofScience,和谷歌学者)，从成立到2020年5月31日。使用改良的纽卡斯尔-渥太华量表对检索到的研究进行质量评估。采用OpenMetaAnalyst软件进行统计分析。
结果：这项荟萃分析纳入了32项纳入21024名孕妇的研究。所有32项研究都是在非洲进行的。在这些研究中,19、11和2调查了S.Mansoni，S、嗜血杆菌，结合曼氏链球菌和埃博拉链球菌感染，分别。妊娠期血吸虫病的合并患病率估计为13.2%(95CI11.0-15.4)。由于高度异质性(Q=99.14;P<0.001),使用随机模型。在亚组分析中，合并的血吸虫流行率估计值显著高于合并的曼氏血吸虫流行率估计值[22.5%(95%CI1.6-43.5)对8.7%(95%CI6.0-11.3,P=0.016),分别]。荟萃回归分析结果显示，根据研究样本量和发表年份，妊娠期血吸虫病患病率无显著差异。只有6项研究评估了妊娠期血吸虫病与贫血之间的关系。6项研究中血吸虫病与贫血相关(OR=3.02,95%=1.25~7.28,P=0.014)。
结论：本荟萃分析提示妊娠期血吸虫病是一个现存的健康问题。这项荟萃分析还强调了缺乏有关怀孕期间血吸虫病的决定因素和结局的数据。在血吸虫病流行地区，需要采取预防措施，并可能成为产前护理的一部分。
