Abstract：
OBJECTIVE: To evaluate IP-10 gene expression in patients with SLE, and its possible relationship with disease activity.
METHODS: This study included 120 patients diagnosed with SLE and 30 healthy controls. The relative gene expression of IP-10 was investigated with the Fold Change method, which was correlated with the level of lupus activity evaluated with the SLEDAI 2-K instrument.
RESULTS: Different levels of gene expression were found according to the SLE activity (p =<0.001). IP-10 gene expression levels were higher in patients with severe activity than in those with no activity, low activity, and moderate activity. The increase in gene expression in the severe activity group was significant with a Fold Change of 3.
CONCLUSIONS: The significant increase in relative gene expression IP-10 may be a marker of severe lupus activity.
METHODS: This study included 120 patients diagnosed with SLE and 30 healthy controls. The relative gene expression of IP-10 was investigated with the Fold Change method, which was correlated with the level of lupus activity evaluated with the SLEDAI 2-K instrument.
RESULTS: Different levels of gene expression were found according to the SLE activity (p =<0.001). IP-10 gene expression levels were higher in patients with severe activity than in those with no activity, low activity, and moderate activity. The increase in gene expression in the severe activity group was significant with a Fold Change of 3.
CONCLUSIONS: The significant increase in relative gene expression IP-10 may be a marker of severe lupus activity.
摘要：
目的：评估SLE患者IP-10基因的表达，以及它与疾病活动的可能关系。
方法：本研究包括120例诊断为SLE的患者和30例健康对照。用倍数变化法研究了IP-10的相对基因表达，这与用SLEDAI2-K仪器评估的狼疮活动水平相关。
结果：根据SLE活性发现不同水平的基因表达（p=<0.001）。IP-10基因表达水平在重度活动患者中高于无活动患者,低活性,适度的活动。在严重活动组中基因表达的增加是显著的,倍数变化为3。
结论：相对基因表达IP-10的显着增加可能是严重狼疮活动的标志。
方法：本研究包括120例诊断为SLE的患者和30例健康对照。用倍数变化法研究了IP-10的相对基因表达，这与用SLEDAI2-K仪器评估的狼疮活动水平相关。
结果：根据SLE活性发现不同水平的基因表达（p=<0.001）。IP-10基因表达水平在重度活动患者中高于无活动患者,低活性,适度的活动。在严重活动组中基因表达的增加是显著的,倍数变化为3。
结论：相对基因表达IP-10的显着增加可能是严重狼疮活动的标志。
