PDF(Pubmed)
Abstract：
OBJECTIVE: This study was planned to evaluate the genetic diversity in the admixed and Teli (a Hindu caste) populations of Maharashtra, India using 20 autosomal Short Tandem Repeat (STR) genetic markers. We further investigated the genetic relatedness of the studied populations with other Indian populations.
RESULTS: The studied populations showed a wide range of observed heterozygosity viz. 0.690 to 0.918 for the admixed population and 0.696 to 0.942 for the Teli population. This might be due to the multi-directional gene flow. The admixed and Teli populations also showed a high degree polymorphism which ranged from 0.652 to 0.903 and 0.644 to 0.902, respectively. Their combined value of matching probability for all the studied loci was 4.29 × 10-25 and 5.01 × 10-24, respectively. The results of Neighbor-Joining tree and Principal Component Analysis showed that the studied populations clustered with the general populations of Jharkhand, UttarPradesh, Rajasthan and Central Indian States, as well as with the specific populations of Maharashtra (Konkanastha Brahmins) and Tamil Nadu (Kurmans). Overall, the obtained data showed a high degree of forensic efficacy and would be useful for forensic applications as well as genealogical studies.
RESULTS: The studied populations showed a wide range of observed heterozygosity viz. 0.690 to 0.918 for the admixed population and 0.696 to 0.942 for the Teli population. This might be due to the multi-directional gene flow. The admixed and Teli populations also showed a high degree polymorphism which ranged from 0.652 to 0.903 and 0.644 to 0.902, respectively. Their combined value of matching probability for all the studied loci was 4.29 × 10-25 and 5.01 × 10-24, respectively. The results of Neighbor-Joining tree and Principal Component Analysis showed that the studied populations clustered with the general populations of Jharkhand, UttarPradesh, Rajasthan and Central Indian States, as well as with the specific populations of Maharashtra (Konkanastha Brahmins) and Tamil Nadu (Kurmans). Overall, the obtained data showed a high degree of forensic efficacy and would be useful for forensic applications as well as genealogical studies.
摘要：
目的：这项研究计划评估马哈拉施特拉邦混合和泰里（印度教种姓）种群的遗传多样性，印度使用20个常染色体短串联重复(STR)遗传标记。我们进一步调查了所研究人群与其他印度人群的遗传相关性。
结果：研究的种群显示出广泛的观察到的杂合性。混合人群为0.690至0.918，Teli人群为0.696至0.942。这可能是由于多方向的基因流动。混合和Teli种群也显示出高度多态性，分别为0.652至0.903和0.644至0.902。所有研究基因座的匹配概率组合值分别为4.29×10-25和5.01×10-24。邻居加入树和主成分分析的结果表明，研究的种群与Jharkhand的一般种群聚集在一起，北方邦,拉贾斯坦邦和中印度各州，以及马哈拉施特拉邦（KonkanasthaBrahmins）和泰米尔纳德邦（Kurmans）的特定人口。总的来说,获得的数据显示出高度的法医学效力，对于法医学应用和家谱研究都很有用。
结果：研究的种群显示出广泛的观察到的杂合性。混合人群为0.690至0.918，Teli人群为0.696至0.942。这可能是由于多方向的基因流动。混合和Teli种群也显示出高度多态性，分别为0.652至0.903和0.644至0.902。所有研究基因座的匹配概率组合值分别为4.29×10-25和5.01×10-24。邻居加入树和主成分分析的结果表明，研究的种群与Jharkhand的一般种群聚集在一起，北方邦,拉贾斯坦邦和中印度各州，以及马哈拉施特拉邦（KonkanasthaBrahmins）和泰米尔纳德邦（Kurmans）的特定人口。总的来说,获得的数据显示出高度的法医学效力，对于法医学应用和家谱研究都很有用。
