Abstract：
The extracellular matrix is a fundamental, core component of all tissues and organs, and is essential for the existence of multicellular organisms. From the earliest stages of organism development until death, it regulates and fine-tunes every cellular process in the body. In cancer, the extracellular matrix is altered at the biochemical, biomechanical, architectural and topographical levels, and recent years have seen an exponential increase in the study and recognition of the importance of the matrix in solid tumours. Coupled with the advancement of new technologies to study various elements of the matrix and cell-matrix interactions, we are also beginning to see the deployment of matrix-centric, stromal targeting cancer therapies. This Review touches on many of the facets of matrix biology in solid cancers, including breast, pancreatic and lung cancer, with the aim of highlighting some of the emerging interactions of the matrix and influences that the matrix has on tumour onset, progression and metastatic dissemination, before summarizing the ongoing work in the field aimed at developing therapies to co-target the matrix in cancer and cancer metastasis.
摘要：
细胞外基质是一种基本的，所有组织和器官的核心部件，对于多细胞生物的存在至关重要。从生物体发育的最早阶段直到死亡，它调节和微调身体的每个细胞过程。在癌症中，细胞外基质在生化改变，生物力学,建筑和地形水平，近年来，对基质在实体肿瘤中的重要性的研究和认识呈指数增长。加上新技术的进步，研究基质和细胞-基质相互作用的各种元素，我们也开始看到以矩阵为中心的部署，基质靶向癌症治疗。这篇综述涉及实体癌基质生物学的许多方面，包括乳房,胰腺癌和肺癌，为了强调基质的一些新出现的相互作用以及基质对肿瘤发病的影响，进展和转移性播散，在总结该领域正在进行的工作之前，旨在开发在癌症和癌症转移中共同靶向基质的疗法。
