PDF(Pubmed)
Abstract：
The looming problem of resistance to antibiotics in microorganisms is a global health concern. The drug-resistant microorganisms originating from anthropogenic sources and commercial livestock farming have posed serious environmental and health challenges. Antibiotic-resistant genes constituting the environmental \"resistome\" get transferred to human and veterinary pathogens. Hence, deciphering the origin, mechanism and extreme of transfer of these genetic factors into pathogens is extremely important to develop not only the therapeutic interventions to curtail the infections, but also the strategies to avert the menace of microbial drug-resistance. Clinicians, researchers and policymakers should jointly come up to develop the strategies to prevent superfluous exposure of pathogens to antibiotics in non-clinical settings. This article highlights the present scenario of increasing antimicrobial-resistance in pathogenic bacteria and the clinical importance of unconventional or non-antibiotic therapies to thwart the infectious pathogenic microorganisms.
摘要：
微生物对抗生素耐药性的迫在眉睫的问题是全球健康问题。源自人为来源和商业家畜养殖的耐药微生物对环境和健康提出了严重的挑战。构成环境“抗性组”的抗生素抗性基因被转移到人类和兽医病原体。因此，破译起源，将这些遗传因素转移到病原体中的机制和极端情况对于开发不仅减少感染的治疗干预措施非常重要，以及避免微生物耐药性威胁的策略。临床医生,研究人员和政策制定者应共同制定策略,以防止病原体在非临床环境中过度暴露于抗生素.本文重点介绍了当前病原菌中抗菌素耐药性增加的情况以及非常规或非抗生素疗法阻止传染性病原微生物的临床重要性。
