Abstract：
Gentamicin ointment has potential in the treatment of Nagashima-type palmoplantar keratosis. However, there is a lack of reliable study data. The aim of this study was to perform a prospective, randomized, double-blinded, contralateral, vehicle-controlled clinical trial. A total of 20 subjects diagnosed with Nagashima-type palmoplantar keratosis by genetic test, who carried nonsense mutations, enrolled in the 30-day study. Gentamicin ointment was applied to the hand and foot on one side of the body, and vehicle ointment was applied to the hand and foot on the other side. The choice of hand and foot in each subject was randomly allocated. The severity of the patient\'s skin lesions and quality of life were assessed by a blinded evaluator, using the Dermatology Life Quality Index, visual analogue scale scores and digital photography. Gentamicin ointment treatment resulted in a significant improvement in symptoms of hyperkeratosis and foul smell compared with vehicle. No difference was found in the effect on erythema between gentamicin and vehicle. In conclusion, gentamicin ointment demonstrated positive responses and good tolerance in treating Nagashima-type palmoplantar keratosis caused by nonsense mutations.
摘要：
庆大霉素软膏具有治疗Nagashima型掌plant角化病的潜力。然而,缺乏可靠的研究数据。这项研究的目的是进行前瞻性的，随机化，双盲,对侧,车辆对照临床试验。共有20名受试者通过基因测试诊断为长岛型掌fat角化病，携带无意义突变的人，参加了30天的研究。将庆大霉素软膏涂在身体一侧的手和脚上，并在另一侧的手和脚上涂抹赋形剂软膏。每个受试者的手和脚的选择是随机分配的。患者皮肤病变的严重程度和生活质量由盲法评估，使用皮肤病学生活质量指数，视觉模拟量表评分和数码摄影。与赋形剂相比，庆大霉素软膏治疗可明显改善角化过度和恶臭的症状。庆大霉素和媒介物对红斑的影响没有差异。总之,庆大霉素软膏在治疗由无义突变引起的长岛型掌plant角化病中表现出积极的反应和良好的耐受性。
