PDF(Sci-hub)
Abstract：
Chitosan is a natural polysaccharide extracted from the shells of crustaceans that has been proposed as a scaffold in tissue engineering. Certain studies have proven a greater osseointegration of titanium surfaces that are functionalized with chitosan. The MEDLINE, CENTRAL, PubMed, and Web of Science databases were electronically searched for in vivo studies. Seven studies met the inclusion criteria. Animal models, implant site, chitosan incorporation methods, and methods of analysis were emphasized. The selected studies were individually discussed regarding the coatings, osseointegration potential, and suitability of the experimental models used, analyzing their limitations. We concluded that chitosan-biofunctionalized titanium surfaces have greater osseointegration capacity that uncoated control titanium alloys.
摘要：
壳聚糖是从甲壳类动物的壳中提取的天然多糖，已被提议作为组织工程中的支架。某些研究已经证明用壳聚糖官能化的钛表面具有更大的骨整合。MEDLINE,中部,PubMed,和WebofScience数据库被电子搜索以进行体内研究。7项研究符合纳入标准。动物模型,植入部位,壳聚糖掺入方法，并强调了分析方法。选定的研究分别讨论了关于涂层，骨整合潜力，以及所用实验模型的适用性，分析其局限性。我们得出的结论是，壳聚糖生物功能化的钛表面具有比未涂覆的对照钛合金更大的骨整合能力。
