FD patients filled out a dyspepsia symptom severity score. Intragastric pressure (IGP) was measured with high-resolution manometry (HRM) during the intragastric infusion of nutrition drink (ND, 1.5 Kcal/ml, 60 ml/min) until maximal satiation in healthy subjects and FD. We compared IGP profiles and nutrient tolerance in HS and FD with or without JHS.
JHS was present in 54% of FD patients (n = 39, 41.2 ± 2.2 years old) and 7% of healthy subjects (n = 15, 27.3 ± 2.3 years old). IGP drop and nutrient tolerance were lower in non-JHS-FD compared with JHS-FD and HS (AUC JHS-FD: -17.9 ± 2.5 vs. non-JHS-FD: -13.0 ± 3.3 mmHg min, p = 0.2, HS:-19.6 ± 2.9 mmHg min; ND tolerance non-JHS-FD: 671.0 ± 96.0 vs. JHS-FD: 842.7 ± 105.7 Kcal, p = 0.25, HS: 980.0 ± 108.1 Kcal).
JHS often co-exists with FD. Non-JHS-FD was characterized by decreased accommodation and lower nutrient tolerance characterized compared with JHS-FD. Clinicaltrials.gov, reference number NCT04279990.
FD患者填写了消化不良症状严重程度评分。在胃内输注营养饮料(ND,1.5千卡/毫升,60ml/min),直到健康受试者和FD的最大饱腹感。我们比较了有或没有JHS的HS和FD的IGP谱和养分耐受性。
54%的FD患者(n=39,41.2±2.2岁)和7%的健康受试者(n=15,27.3±2.3岁)存在JHS。与JHS-FD和HS相比,非JHS-FD的IGP下降和养分耐受性较低(AUCJHS-FD:-17.9±2.5vs.非JHS-FD:-13.0±3.3mmHgmin,p=0.2,HS:-19.6±2.9mmHgmin;ND容差非JHS-FD:671.0±96.0vs.JHS-FD:842.7±105.7大卡,p=0.25,HS:980.0±108.1大卡)。
JHS经常与FD共存。与JHS-FD相比,非JHS-FD的特征是适应性降低和养分耐受性降低。Clinicaltrials.gov,参考号NCT04279990。