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Abstract：
Among the in vivo experimental models, the chick embryo chorioallantoic membrane (CAM) has been routinely used to implant several malignant cell lines or tumor tissues to study their angiogenic and metastatic capability. Since the chick embryo is naturally immunodeficient, the CAM can support the engraftment of tumor cells, and their growth therein can faithfully recapitulate most of the characteristics of the carcinogenic process including: growth, invasion, angiogenesis and colonization of distant tissues. This review article is focused on the discussion of the more recent literature data concerning the use of the CAM to investigate the metastatic process.
摘要：
在体内实验模型中，鸡胚绒毛尿囊膜（CAM）已常规用于植入几种恶性细胞系或肿瘤组织，以研究其血管生成和转移能力。由于小鸡胚胎是天然免疫缺陷的，CAM可以支持肿瘤细胞的植入，它们在其中的生长可以忠实地概括致癌过程的大部分特征，包括:生长，入侵,血管生成和远处组织的定植。这篇综述文章的重点是讨论有关使用CAM研究转移过程的最新文献数据。
